Novel soluble epoxide hydrolase inhibitors with a dihydropyrimidinone scaffold: design, synthesis and biological evaluation

MedChemComm ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 2128-2135 ◽  
Author(s):  
Elham Rezaee ◽  
Mahdi Hedayati ◽  
Laleh Hoghooghi Rad ◽  
Soraya Shahhosseini ◽  
Mehrdad Faizi ◽  
...  
Keyword(s):  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Biological Evaluation ◽  
Scaffold Design ◽  
Urea Derivatives ◽  
Design Synthesis ◽  
Soluble Epoxide Hydrolase Inhibitors ◽  
Synthesis And Biological Evaluation

Amide non-urea derivatives with a dihydropyrimidinone ring as a novel secondary pharmacophore against the sEH enzyme were designed, synthesized and biologically evaluated.

Design, synthesis, and biological evaluation of tetrahydroisoquinoline-based diaryl urea derivatives for suppressing VEGFR-2 signaling

2019 ◽  
Vol 30 (5) ◽  
pp. 508-516 ◽  
Author(s):  
Yuanzheng Huang ◽  
Yang Zhang ◽  
Jiaming Li ◽  
Xiaodong Ma ◽  
Mengqi Hu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Urea Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase

2015 ◽  
Vol 58 (12) ◽  
pp. 4984-4997 ◽  
Author(s):  
Akihiro Sugawara ◽  
Nobuo Maita ◽  
Hiroaki Gouda ◽  
Tsuyoshi Yamamoto ◽  
Tomoyasu Hirose ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Scaffold Design ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of biphenyl urea derivatives as novel VEGFR-2 inhibitors

MedChemComm ◽  
2013 ◽  
Vol 4 (11) ◽  
pp. 1434 ◽  
Author(s):  
Chen Wang ◽  
Jinyun Dong ◽  
Yanmin Zhang ◽  
Fang Wang ◽  
Hongping Gao ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Urea Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
Sign in / Sign up

Export Citation Format

Share Document