Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors

2021 ◽  
Vol 109 ◽  
pp. 104736
Author(s):  
Yucheng Zhong ◽  
Jing Liu ◽  
Xiangyu Cheng ◽  
Hao Zhang ◽  
Chunhua Zhang ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Hybrid Molecules ◽  
Michael Acceptor

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

scholarly journals Hybrid cis-stilbene Molecules: Novel Anticancer Agents

2019 ◽  
Vol 20 (6) ◽  
pp. 1300 ◽  
Author(s):  
Natalia Piekuś-Słomka ◽  
Renata Mikstacka ◽  
Joanna Ronowicz ◽  
Stanisław Sobiak
Keyword(s):  
Anticancer Agents ◽  
Biological Activities ◽  
Distinct Group ◽  
Design Synthesis ◽  
Drug Candidates ◽  
Structure Activity ◽  
Polymerization Inhibitor ◽  
Hybrid Molecules ◽  
Tubulin Polymerization Inhibitor ◽  
Pharmacologically Active

The growing interest in anticancer hybrids in the last few years has resulted in a great number of reports on hybrid design, synthesis and bioevaluation. Many novel multi-target-directed drug candidates were synthesized, and their biological activities were evaluated. For the design of anticancer hybrid compounds, the molecules of stilbenes, aromatic quinones, and heterocycles (benzimidazole, imidazole, pyrimidine, pyridine, pyrazole, quinoline, quinazoline) were applied. A distinct group of hybrids comprises the molecules built with natural compounds: Resveratrol, curcumin, coumarin, and oleanolic acid. In this review, we present the studies on bioactive hybrid molecules of a well-known tubulin polymerization inhibitor, combretastatin A-4 and its analogs with other pharmacologically active entities. The mechanism of anticancer activity of selected hybrids is discussed considering the structure-activity relationship.

Design, synthesis and biological evaluations of novel pyridone-thiazole hybrid molecules as antitumor agents

2018 ◽  
Vol 145 ◽  
pp. 35-40 ◽  
Author(s):  
Wenlin Xie ◽  
Yiqiang Wu ◽  
Jingai Zhang ◽  
Qihong Mei ◽  
Yahan Zhang ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Design Synthesis ◽  
Hybrid Molecules

Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds

2018 ◽  
Vol 144 ◽  
pp. 493-503 ◽  
Author(s):  
Jiabing Wang ◽  
Di Yun ◽  
Jiali Yao ◽  
Weitao Fu ◽  
Fangyan Huang ◽  
...  
Keyword(s):  
Qsar Study ◽  
Anticancer Compounds ◽  
Design Synthesis ◽  
Michael Acceptor

scholarly journals Structure based design, synthesis and activity studies of small hybrid molecules as HDAC and G9a dual inhibitors

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 63187-63207 ◽  
Author(s):  
Lanlan Zang ◽  
Shukkoor M. Kondengaden ◽  
Qing Zhang ◽  
Xiaobo Li ◽  
Dilep K. Sigalapalli ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Hybrid Molecules ◽  
Dual Inhibitors
Sign in / Sign up

Export Citation Format

Share Document