Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds

2018 ◽  
Vol 144 ◽  
pp. 493-503 ◽  
Author(s):  
Jiabing Wang ◽  
Di Yun ◽  
Jiali Yao ◽  
Weitao Fu ◽  
Fangyan Huang ◽  
...  
Keyword(s):  
Qsar Study ◽  
Anticancer Compounds ◽  
Design Synthesis ◽  
Michael Acceptor

scholarly journals Design, synthesis and QSAR study of 2′-hydroxy-4′-alkoxy chalcone derivatives that exert cytotoxic activity by the mitochondrial apoptotic pathway

2019 ◽  
Vol 27 (1) ◽  
pp. 43-54 ◽  
Author(s):  
Silvia Marquina ◽  
Maritza Maldonado-Santiago ◽  
Jessica Nayelli Sánchez-Carranza ◽  
Mayra Antúnez-Mojica ◽  
Leticia González-Maya ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Qsar Study ◽  
Apoptotic Pathway ◽  
Design Synthesis ◽  
Mitochondrial Apoptotic Pathway ◽  
Chalcone Derivatives

Design, synthesis, and QSAR study of novel 2-(2,3-dioxo-2,3-dihydro-1H-indol-1-yl)-N-phenylacetamide derivatives as cytotoxic agents

2010 ◽  
Vol 20 (5) ◽  
pp. 615-625 ◽  
Author(s):  
Neha R. Modi ◽  
Ravi J. Shah ◽  
Manish J. Patel ◽  
Maulik Suthar ◽  
Bhupendrasinh F. Chauhan ◽  
...  
Keyword(s):  
Cytotoxic Agents ◽  
Qsar Study ◽  
Design Synthesis

scholarly journals Novel Chrysin-De-Allyl PAC-1 Hybrid Analogues as Anticancer Compounds: Design, Synthesis, and Biological Evaluation

Molecules ◽  
2020 ◽  
Vol 25 (13) ◽  
pp. 3063
Author(s):  
Buthina A. Al-Oudat ◽  
Hariteja Ramapuram ◽  
Saloni Malla ◽  
Suaad A. Audat ◽  
Noor Hussein ◽  
...  
Keyword(s):  
Mammary Epithelial Cells ◽  
Biological Evaluation ◽  
Mammary Epithelial ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Anticancer Compounds ◽  
Design Synthesis ◽  
Apoptotic Pathways ◽  
Induced Apoptosis

New chrysin-De-allyl-Pac-1 hybrid analogues, tethered with variable heterocyclic systems (4a–4o), were rationally designed and synthesized. The target compounds were screened for in vitro antiproliferative efficacy in the triple-negative breast cancer (TNBC) cell line, MDA-MB-231, and normal human mammary epithelial cells (HMECs). Two compounds, 4g and 4i, had the highest efficacy and selectivity towards MDA-MB-231 cells, and thus, were further evaluated by mechanistic experiments. The results indicated that both compounds 4g and 4i induced apoptosis by (1) inducing cell cycle arrest at the G2 phase in MDA-MB-231 cells, and (2) activating the intrinsic apoptotic pathways in a concentration-dependent manner. Physicochemical characterizations of these compounds suggested that they can be further optimized as potential anticancer compounds for TNBC cells. Overall, our results suggest that 4g and 4i could be suitable leads for developing novel compounds to treat TNBC.

2-Methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted Trichomonas : Design, synthesis, biology and 3D-QSAR study

2016 ◽  
Vol 124 ◽  
pp. 820-839 ◽  
Author(s):  
Dhanaraju Mandalapu ◽  
Bhavana Kushwaha ◽  
Sonal Gupta ◽  
Nidhi Singh ◽  
Mahendra Shukla ◽  
...  
Keyword(s):  
3D Qsar ◽  
Qsar Study ◽  
Design Synthesis ◽  
Sexually Transmitted

Quinazoline based 1,3,5‐triazine derivatives as cancer inhibitors by impeding the phosphorylated RET tyrosine kinase pathway: Design, synthesis, docking, and QSAR study

2019 ◽  
Vol 352 (9) ◽  
pp. 1900053 ◽  
Author(s):  
Prateek Pathak ◽  
Vladislav Naumovich ◽  
Maria Grishina ◽  
Parjanya Kumar Shukla ◽  
Amita Verma ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Qsar Study ◽  
Design Synthesis ◽  
Triazine Derivatives ◽  
Kinase Pathway

Novel pyrrolidine-2,4-dione derivatives containing pharmacophores of both hydrazine and diphenyl ether as potential antifungal agents: design, synthesis, biological evaluation, and 3D-QSAR study

2020 ◽  
Vol 44 (46) ◽  
pp. 20071-20082
Author(s):  
Hao-Ran Hu ◽  
An Wang ◽  
Ling-Ling Qiu ◽  
Xiao-Bin Wang ◽  
Min Chen ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Antifungal Activity ◽  
Antifungal Agents ◽  
Diphenyl Ether ◽  
3D Qsar ◽  
Biological Evaluation ◽  
Qsar Study ◽  
Design Synthesis ◽  
Scanning Electron

Novel pyrrolidine-2,4-dione derivatives were designed based on natural products. Some synthesized compounds showed excellent antifungal activity. Scanning electron microscopy was used to observe mycelium morphology. 3D-QSAR was also studied.

Design, synthesis and 2D QSAR study of novel pyridine and quinolone hydrazone derivatives as potential antimicrobial and antitubercular agents

2017 ◽  
Vol 138 ◽  
pp. 698-714 ◽  
Author(s):  
Mohamed A. Abdelrahman ◽  
Ismail Salama ◽  
Mohamed S. Gomaa ◽  
Mahmoud M. Elaasser ◽  
Marwa M. Abdel-Aziz ◽  
...  
Keyword(s):  
Antitubercular Agents ◽  
Qsar Study ◽  
Design Synthesis ◽  
2D Qsar

Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives

2010 ◽  
Vol 15 (3) ◽  
pp. 665-675 ◽  
Author(s):  
Lili Ou ◽  
Shuang Han ◽  
Wenbo Ding ◽  
Zhe Chen ◽  
Ziqi Ye ◽  
...  
Keyword(s):  
3D Qsar ◽  
Qsar Study ◽  
Design Synthesis
Sign in / Sign up

Export Citation Format

Share Document