Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents

2021 ◽  
Vol 116 ◽  
pp. 105292
Author(s):  
Thiago A. Grigolo ◽  
Carolyne B. Braga ◽  
Catia Ornelas ◽  
Dennis Russowsky ◽  
Guilherme A. Ferreira-Silva ◽  
...  
Keyword(s):  
Antiproliferative Agents ◽  
Derivatives Of

ChemInform Abstract: Unsymmetrical Methylene Derivatives of Indoles as Antiproliferative Agents.

ChemInform ◽  
2010 ◽  
Vol 33 (19) ◽  
pp. no-no
Author(s):  
Mauro Mazzei ◽  
Mariangela Miele ◽  
Erika Nieddu ◽  
Federica Barbieri ◽  
Cristina Bruzzo ◽  
...  
Keyword(s):  
Antiproliferative Agents ◽  
Derivatives Of

Design and synthesis of novel N,N′-glycoside derivatives of 3,3′-diindolylmethanes as potential antiproliferative agents

MedChemComm ◽  
2012 ◽  
Vol 3 (9) ◽  
pp. 1082 ◽  
Author(s):  
Deepak K. Sharma ◽  
Bilal Rah ◽  
Mallikharjuna R. Lambu ◽  
Altaf Hussain ◽  
Syed K. Yousuf ◽  
...  
Keyword(s):  
Antiproliferative Agents ◽  
Design And Synthesis ◽  
Derivatives Of

Synthesis of methyl derivatives of 8-desmethylxanthyletine and 8-desmethylseseline, potential antiproliferative agents

1987 ◽  
Vol 24 (2) ◽  
pp. 485-488 ◽  
Author(s):  
P. Rodighiero ◽  
P. Manzini ◽  
G. Pastorini ◽  
F. Bordin ◽  
A. Guiotto
Keyword(s):  
Antiproliferative Agents ◽  
Methyl Derivatives ◽  
Derivatives Of

Synthesis of new derivatives of 3-aryl-1,5-dimethyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazines as potential antiproliferative agents

2010 ◽  
Vol 48 (1) ◽  
pp. 183-187 ◽  
Author(s):  
Mehdi Bakavoli ◽  
Mohammad Rahimizadeh ◽  
Ali Shiri ◽  
Marzieh Akbarzadeh ◽  
Seyed-Hadi Mousavi ◽  
...  
Keyword(s):  
Antiproliferative Agents ◽  
Derivatives Of

Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents

2020 ◽  
Vol 208 ◽  
pp. 112789
Author(s):  
Jun-Feng Huo ◽  
Tian-Xing Hu ◽  
Ya-Long Dong ◽  
Jin-Zhu Zhao ◽  
Xiao-Jie Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Antiproliferative Agents ◽  
Derivatives Of

Thio-substituted derivatives of 4-amino-pyrazolo[3,4-d]pyrimidine-6-thiol as antiproliferative agents

2021 ◽  
Author(s):  
Barbara Cacciari ◽  
Romeo Romagnoli ◽  
Arianna Romani ◽  
Alessandro Trentini ◽  
Stefania Hanau
Keyword(s):  
Cell Death ◽  
Dna Replication ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
High Selectivity ◽  
Antiproliferative Agents ◽  
Drug Candidates ◽  
A Value ◽  
New Compounds ◽  
Derivatives Of

The current study was designed to identify new compounds as potential antiproliferative drug candidates. Synthesis of heteroaromatic bicyclic and monocyclic derivatives as purine bioisosters was employed. Their antiproliferative activity was studied against U937 cancer cells. The most effective compounds were evaluated for their selectivity against cancer cells, the possible mechanism of cell death, and their interference with DNA replication. Among the synthesized compounds, only three (4b, 4j and 4l) demonstrated a value of IC50 less than 20 μM. However, two of them (4b and 4l) were specific against cancer cells, with 4l presenting high selectivity. The presence of substituted pyrazolo[3,4- d]pyrimidine core is as essential for this activity as the presence of substituents at the thiol function in 6-position.

ChemInform Abstract: Synthesis of New Derivatives of 3-Aryl-1,5-dimethyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e] [1,3,4]oxadiazines as Potential Antiproliferative Agents.

ChemInform ◽  
2011 ◽  
Vol 42 (25) ◽  
pp. no-no
Author(s):  
Mehdi Bakavoli ◽  
Mohammad Rahimizadeh ◽  
Ali Shiri ◽  
Marzieh Akbarzadeh ◽  
Seyed-Hadi Mousavi ◽  
...  
Keyword(s):  
Antiproliferative Agents ◽  
Derivatives Of
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