Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors

2021 ◽  
pp. 105456
Author(s):  
Sadia Abbas ◽  
Saira Afzal ◽  
Humaira Nadeem ◽  
Dilawar Hussain ◽  
Peter Langer ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Nucleoside Triphosphate ◽  
Amide Derivatives

Synthesis and biological evaluation of 1,3,4-oxadiazole fused tetrazole amide derivatives as anticancer agents

2020 ◽  
Vol 30 ◽  
pp. 100548
Author(s):  
Ravindar Kotla ◽  
Adharvana Chari Murugulla ◽  
Radhakrishnamraju Ruddarraju ◽  
Mandava Venkata Basaveswara Rao ◽  
P. Aparna ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Amide Derivatives ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of amide derivatives of diflunisal as potential anti-tumor agents

2009 ◽  
Vol 19 (15) ◽  
pp. 4399-4402 ◽  
Author(s):  
Guang-Xiang Zhong ◽  
Lu-Lu Chen ◽  
Hai-Bo Li ◽  
Fu-Jin Liu ◽  
Jin-Qing Hu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Amide Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

scholarly journals Structure-Based Discovery and Synthesis of Potential Transketolase Inhibitors

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2116 ◽  
Author(s):  
Jingqian Huo ◽  
Bin Zhao ◽  
Zhe Zhang ◽  
Jihong Xing ◽  
Jinlin Zhang ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Structural Similarity ◽  
Biological Evaluation ◽  
Dynamics Simulation ◽  
Antifungal Activities ◽  
Protein Model ◽  
Zinc Database ◽  
Amide Derivatives ◽  
Plant Photosynthesis ◽  
New Compounds

Transketolase (TKL) plays a key role in plant photosynthesis and has been predicted to be a potent herbicide target. Homology modeling and molecular dynamics simulation were used to construct a target protein model. A target-based virtual screening was developed to discover novel potential transketolase inhibitors. Based on the receptor transketolase 1 and a target-based virtual screening combined with structural similarity, six new compounds were selected from the ZINC database. Among the structural leads, a new compound ZINC12007063 was identified as a novel inhibitor of weeds. Two novel series of carboxylic amide derivatives were synthesized, and their structures were rationally identified by NMR and HRMS. Biological evaluation of the herbicidal and antifungal activities indicated that the compounds 4u and 8h were the most potent herbicidal agents, and they also showed potent fungicidal activity with a relatively broad-spectrum. ZINC12007063 was identified as a lead compound of potential transketolase inhibitors, 4u and 8h which has the herbicidal and antifungal activities were synthesized based on ZINC12007063. This study lays a foundation for the discovery of new pesticides.

Synthesis and Biological Evaluation of some Amide Derivatives Bearing Benzothiazole and Piperidine Moieties as Antimicrobial Agents

2013 ◽  
Vol 10 (5) ◽  
pp. 453-461 ◽  
Author(s):  
Mehlika Dilek Altintop ◽  
Ahmet Ozdemir ◽  
Zafer Asim Kaplancikli ◽  
Gulhan Turan-Zitouni ◽  
Gokalp Iscan ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Amide Derivatives ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of 12-benzyl matrinic amide derivatives as a novel family of anti-HCV agents

2016 ◽  
Vol 27 (7) ◽  
pp. 1052-1057 ◽  
Author(s):  
Sheng Tang ◽  
Zong-Gen Peng ◽  
Xin Zhang ◽  
Xin-Yue Cheng ◽  
Wen-Jing Li ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Amide Derivatives ◽  
Synthesis And Biological Evaluation
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