Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients

In patients with orofacial cleft, toothpaste they use should demonstrate anti-inflammatory, antibacterial and regenerative action and at the same time be well-tolerated by the oral cavity epithelium and characterized by low toxicity. For this reason, it is expedient to seek preparations that would show the properties described above and could be used as auxiliary means supporting the maintenance of oral health in patients with orofacial clefts. Aim. The aim of the study was to perform a comparative assessment of toothpaste containing Polish propolis in combination with plant oils with that containing Brazilian propolis on the oral cavity condition in patients with orofacial cleft treated with removable appliances. Material and methods. The study material included 75 patients eligible for the study with a cleft lip or cleft lip and palate treated orthodontically. They were divided into three groups, A, B and C. Group A received a toothpaste with 2 % ethanol extract of Polish propolis (EEP-P) and plant oils, 0.5% tea tree oil (TTO), 0.2% menthol oil (MO), and 0.1% rosemary oil (RO). Group B received a toothpaste with 3% ethanol extract of Brazilian propolis (EEP-B). Group C included patients who were given a placebo toothpaste devoid of any active substances. During the baseline (first) and a follow-up (final) examination after 35 days, in each patient the Approximate Plaque Index (API), gingival index (GI) and Bleeding on Probing (BOP) were assessed. Results. The biggest improvement of the gingival condition translated into the GI index and the BOP was found in group A and amounted to 31% and 26% respectively, compared to the baseline examination (p<0.00); a statistically significant reduction of the GI index by 25% and BOP by 29% (p<0.01) was found in group B. No statistically significant differences of the values of the API, GI and BOP indices were found between groups A and B. There was no significant improvement of the gingiva condition in Group C. Conclusions. Both types of toothpaste containing active substances have beneficial effects on the condition of the marginal parodontium and they do not significantly differ in terms of their biological activity in the oral cavity. Besides, the toothpaste with Polish propolis and plant oils has a beneficial effect on the oral cavity hygiene in children with orofacial cleft. (Machorowska-Pieniążek A, Tanasiewicz M, Skucha-Nowak M, Morawiec T. A comparative assessment of effects of Polish propolis combined with plant oils with those of Brazilian propolis on the oral cavity condition in orofacial cleft patients treated with removable appliances. Orthod Forum 2017; 13: 15-27).

Download Full-text

Speech-Language Pathology Services for Individuals With Cleft Lip/Palate in Less Developed Nations: The Operation Smile Approach

Perspectives on Speech Science and Orofacial Disorders ◽

10.1044/ssod8.1.12 ◽

1998 ◽

Vol 8 (1) ◽

pp. 12-14 ◽

Cited By ~ 1

Author(s):

Charlotte A. Ducote

Keyword(s):

Cleft Lip ◽

Speech Language Pathology ◽

Operation Smile ◽

Cleft Lip Palate ◽

Language Pathology ◽

Developed Nations

Download Full-text

Faculty Opinions recommendation of Mutation of PVRL1 is associated with sporadic, non-syndromic cleft lip/palate in northern Venezuela.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1000744.13071 ◽

2001 ◽

Author(s):

Sue Malcolm

Keyword(s):

Cleft Lip ◽

Cleft Lip Palate

Download Full-text

Isoform-Specific Roles of Mutant p63 in Human Diseases

Cancers ◽

10.3390/cancers13030536 ◽

2021 ◽

Vol 13 (3) ◽

pp. 536

Author(s):

Christian Osterburg ◽

Susanne Osterburg ◽

Huiqing Zhou ◽

Caterina Missero ◽

Volker Dötsch

Keyword(s):

Cleft Lip ◽

Ectodermal Dysplasia ◽

Skin Development ◽

Disease Mechanisms ◽

Skin Fragility ◽

Cleft Lip Palate ◽

Life Threatening ◽

Functional Consequences ◽

Development And Differentiation

The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the DNA binding domain cause Ectrodactyly, Ectodermal Dysplasia, characterized by limb deformation, cleft lip/palate, and ectodermal dysplasia while mutations in in the C-terminal domain of the α-isoform cause Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) syndrome, a life-threatening disorder characterized by skin fragility, severe, long-lasting skin erosions, and cleft lip/palate. The molecular disease mechanisms of these syndromes have recently become elucidated and have enhanced our understanding of the role of p63 in epidermal development. Here we review the molecular cause and functional consequences of these p63-mutations for skin development and discuss the consequences of p63 mutations for female fertility.

Download Full-text

Alveolar cleft and maximum cleft width as predictors for difficult laryngoscopy and intubation in patients with unilateral complete cleft lip and palate

Ain-Shams Journal of Anesthesiology ◽

10.1186/s42077-021-00137-7 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Gamal A. Abdelhameed ◽

Wael A. Ghanem ◽

Simon H. Armanios ◽

Tamer Nabil Abdelrahman

Keyword(s):

Body Weight ◽

Odds Ratio ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Difficult Laryngoscopy ◽

Secondary Outcome ◽

Pediatric Airway ◽

Alveolar Cleft ◽

Cleft Lip Palate ◽

Width Measurements

Abstract Background Cleft lip and palate is one of the commonest congenital anomalies, which have an impact on feeding, speech, and dental development away from the significant psychosocial sequel. Early surgical repair aims to restore appearance and function, and the modern techniques can leave many defects undetectable. Therefore, the anesthetic challenge facing the pediatric airway with such abnormalities is still of a great impact. The aim of our study among 189 patients enrolled is to correlate alveolar gap and maximum cleft width measurements as predictors of difficult laryngoscopy and intubation in infants with unilateral complete cleft lip/palate aging from 1 to 6 months. As a secondary outcome, their weight is to be correlated too as another parameter. Results The alveolar gap and maximum cleft width are both of equal high predictive power (p value ≤ 0.001) with 100% sensitivity for both and specificity of 76.10% and 82.39% respectively, with a cut off value of ≤ 10 mm and 11 mm for these dimensions respectively, and odds ratio of incidence of difficult intubation is 4.18 and 5.68 respectively, while body weight ≤ 5.75 kg has an odds ratio of 2.32. Conclusion Alveolar cleft and maximum cleft width can be used as predictors for anticipation of difficult laryngoscopy and intubation infant patients with unilateral complete cleft lip and palate, while body weight ≤ 5.75 kg increases the risk more than twice.

Download Full-text