scholarly journals Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

2022 ◽  
Vol 145 ◽  
pp. 112397
Author(s):  
Zhong-Yuan Tang ◽  
Yang Li ◽  
Yu-Ting Tang ◽  
Xiao-Dong Ma ◽  
Ze-Yao Tang
Keyword(s):  
Anticancer Activity ◽  
Oleanolic Acid ◽  
Mechanisms Of Action ◽  
Recent Advances

Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents

2020 ◽  
Vol 20 (16) ◽  
pp. 1441-1460 ◽  
Author(s):  
Xiaoyue Wen ◽  
Yongqin Zhou ◽  
Junhao Zeng ◽  
Xinyue Liu
Keyword(s):  
Anticancer Activity ◽  
Anticancer Agents ◽  
Mechanisms Of Action ◽  
Triazole Derivatives ◽  
Recent Advances

1,2,4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a 1,2,4-triazole moiety, revealing their potential in the development of novel anticancer agents. This review emphasizes the recent advances in 1,2,4-triazole-containing compounds with anticancer potential, and the structureactivity relationships as well as mechanisms of action are also discussed.

Recent Advances in the Synthesis and Anticancer Activity of Some Molecules Other Than Nitrogen Containing Heterocyclic Moeities

2017 ◽  
Vol 17 (17) ◽  
Author(s):  
Md Jawaid Akhtar ◽  
M. Shahar Yar ◽  
Ahsan Ahmed Khan ◽  
Zulphikar Ali ◽  
Md Rafi Haider
Keyword(s):  
Anticancer Activity ◽  
Recent Advances

scholarly journals Recent advances in nanoparticle formulation of oleanolic acid

2011 ◽  
Vol 6 (1) ◽  
pp. 20 ◽  
Author(s):  
Meiwan Chen ◽  
Zhangfeng Zhong ◽  
Wen Tan ◽  
Shengpeng Wang ◽  
Yitao Wang
Keyword(s):  
Oleanolic Acid ◽  
Recent Advances ◽  
Nanoparticle Formulation

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

2017 ◽  
Vol 37 (6) ◽  
pp. 1492-1517 ◽  
Author(s):  
Yin Kwan Wong ◽  
Chengchao Xu ◽  
Karunakaran A. Kalesh ◽  
Yingke He ◽  
Qingsong Lin ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Mechanisms Of Action ◽  
Recent Advances

scholarly journals Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 610
Author(s):  
Junjie Yan ◽  
Weiwei Liu ◽  
Jiatong Cai ◽  
Yiming Wang ◽  
Dahong Li ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Natural Compounds ◽  
Mechanisms Of Action ◽  
Biosynthetic Pathways ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
The Past ◽  
Synthetic Derivatives

Phenazines are a large group of nitrogen-containing heterocycles, providing diverse chemical structures and various biological activities. Natural phenazines are mainly isolated from marine and terrestrial microorganisms. So far, more than 100 different natural compounds and over 6000 synthetic derivatives have been found and investigated. Many phenazines show great pharmacological activity in various fields, such as antimicrobial, antiparasitic, neuroprotective, insecticidal, anti-inflammatory and anticancer activity. Researchers continued to investigate these compounds and hope to develop them as medicines. Cimmino et al. published a significant review about anticancer activity of phenazines, containing articles from 2000 to 2011. Here, we mainly summarize articles from 2012 to 2021. According to sources of compounds, phenazines were categorized into natural phenazines and synthetic phenazine derivatives in this review. Their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic strategies were summarized. These may provide guidance for the investigation on phenazines in the future.

scholarly journals Emerging mechanisms of dynein transport in the cytoplasm versus the cilium

2018 ◽  
Vol 46 (4) ◽  
pp. 967-982 ◽  
Author(s):  
Anthony J. Roberts
Keyword(s):  
Intraflagellar Transport ◽  
Cytoplasmic Dynein ◽  
Mechanisms Of Action ◽  
Cell Interior ◽  
Long Distance ◽  
Cargo Transport ◽  
Recent Advances ◽  
Human Disorders ◽  
Cilia And Flagella

Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic dynein-1 is responsible for the majority of transport toward microtubule minus ends in the cell interior. Dynein-2, also known as intraflagellar transport dynein, moves cargoes along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances in dynein-1 and -2 research, and probes to what extent the emerging principles of dynein-1 transport could apply to or differ from those of the less well-understood dynein-2 mechanoenzyme.

Recent advances in experimental polyphosphazene adjuvants and their mechanisms of action

2018 ◽  
Vol 374 (3) ◽  
pp. 465-471 ◽  
Author(s):  
Royford Magiri ◽  
George Mutwiri ◽  
Heather L. Wilson
Keyword(s):  
Mechanisms Of Action ◽  
Recent Advances
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