Concordance of Parent-Offspring Cortico-Basal Ganglia White Matter Connectivity: The Role of Parental Depression and Parent-Child Bonding

The human connectome is the complete structural description of the network of connections and elements that form the wiring diagram of the brain. Because of the current scarcity of information regarding laminar end points of white matter tracts inside cortical grey matter, tractography remains focused on cortical partitioning into regions, while ignoring radial partitioning into laminar components. To overcome this biased representation of the cortex as a single homogenous unit, we use a recent data-derived model of cortical laminar connectivity, which has been further explored and corroborated in the macaque brain by comparison to published studies. The model integrates multimodal MRI imaging datasets regarding both white matter connectivity and grey matter laminar composition into a laminar-level connectome. In this study we model the laminar connectome of healthy human brains (N=20) and explore them via a set of neurobiologically meaningful complex network measures. Our analysis demonstrates a subdivision of network hubs that appear in the standard connectome into each individual component of the laminar connectome, giving a fresh look into the role of laminar components in cortical connectivity and offering new prospects in the fields of both structural and functional connectivity.

Download Full-text

White matter connectivity between structures of the basal ganglia using 3T and 7T

Neuroscience ◽

10.1016/j.neuroscience.2021.12.034 ◽

2021 ◽

Author(s):

Jae-Hyuk Shim ◽

Hyeon-Man Baek

Keyword(s):

White Matter ◽

Basal Ganglia ◽

White Matter Connectivity

Download Full-text

Exploring the role of white matter connectivity in cortex maturation

PLoS ONE ◽

10.1371/journal.pone.0177466 ◽

2017 ◽

Vol 12 (5) ◽

pp. e0177466 ◽

Cited By ~ 13

Author(s):

Cecilia L. Friedrichs-Maeder ◽

Alessandra Griffa ◽

Juliane Schneider ◽

Petra Susan Hüppi ◽

Anita Truttmann ◽

...

Keyword(s):

White Matter ◽

White Matter Connectivity

Download Full-text

Parent-Child Role Confusion: Exploring the Role of Family Processes in the Context of Parental Depression

Journal of Clinical Child & Adolescent Psychology ◽

10.1080/15374416.2021.1894943 ◽

2021 ◽

pp. 1-15

Author(s):

Karissa DiMarzio ◽

Justin Parent ◽

Rex Forehand ◽

Jennifer Champion Thigpen ◽

Juliana Acosta ◽

...

Keyword(s):

Parental Depression ◽

Family Processes ◽

Role Confusion ◽

Parent Child

Download Full-text

Concordance in parent and offspring cortico-basal ganglia white matter connectivity varies by parental history of major depressive disorder and early parental care

Social Cognitive and Affective Neuroscience ◽

10.1093/scan/nsaa118 ◽

2020 ◽

Vol 15 (8) ◽

pp. 889-903

Author(s):

Eyal Abraham ◽

Jonathan Posner ◽

Priya J Wickramaratne ◽

Natalie Aw ◽

Milenna T van Dijk ◽

...

Keyword(s):

Major Depressive Disorder ◽

White Matter ◽

Basal Ganglia ◽

Depressive Disorder ◽

Parental Care ◽

Major Depressive ◽

Parental History ◽

History Of ◽

Depressed Parent

Abstract Social behavior is transmitted cross-generationally through coordinated behavior within attachment bonds. Parental depression and poor parental care are major risks for disruptions of such coordination and are associated with offspring’s psychopathology and interpersonal dysfunction. Given the key role of the cortico-basal ganglia (CBG) circuits in social communication, we examined similarities (concordance) of parent–offspring CBG white matter (WM) connections and how parental history of major depressive disorder (MDD) and early parental care moderate these similarities. We imaged 44 parent–offspring dyads and investigated WM connections between basal-ganglia seeds and selected regions in temporal cortex using diffusion tensor imaging (DTI) tractography. We found significant concordance in parent–offspring strength of CBG WM connections, moderated by parental lifetime-MDD and care. The results showed diminished neural concordance among dyads with a depressed parent and that better parental care predicted greater concordance, which also provided a protective buffer against attenuated concordance among dyads with a depressed parent. Our findings provide the first neurobiological evidence of concordance between parents-offspring in WM tracts and that concordance is diminished in families where parents have lifetime-MDD. This disruption may be a risk factor for intergenerational transmission of psychopathology. Findings emphasize the long-term role of early caregiving in shaping the neural concordance among at-risk and affected dyads.

Download Full-text