Localized Task-Invariant Emotional Valence Encoding Revealed by Intracranial Recordings

The ability to distinguish between negative, positive and neutral valence is a key part of emotion perception. Emotional valence has conceptual meaning that supersedes any particular type of stimulus, although it is typically captured experimentally in association with particular tasks. We sought to identify neural encoding for task-invariant emotional valence. We evaluated whether high gamma responses (HGRs) to visually displayed words conveying emotions could be used to decode emotional valence from HGRs to facial expressions. Intracranial electroencephalography (iEEG) was recorded from fourteen individuals while they participated in two tasks, one involving reading words with positive, negative, and neutral valence, and the other involving viewing faces with positive, negative, and neutral facial expressions. Quadratic discriminant analysis was used to identify information in the HGR that differentiates the three emotion conditions. A classifier was trained on the emotional valence labels from one task and was cross-validated on data from the same task (within-task classifier) as well as the other task (between-task classifier). Emotional valence could be decoded in the left medial orbitofrontal cortex and middle temporal gyrus, both using within-task classifiers as well as between-task classifiers. These observations suggest the presence of task-independent emotional valence information in the signals from these regions.

Neural processing associated with Cognitive Empathy in Pedophilia and Child Sexual Offending

Behavioral studies found evidence for superior cognitive empathy (CE) in pedophilic men without a history of child sexual offending (P-CSO) compared to pedophilic men with a history of CSO (P+CSO). Functional magnetic resonance imaging (fMRI) studies also point to differences between P-CSO and P+CSO. Neural processing associated with CE has not yet been investigated. Therefore, the present study aimed to explore the neural correlates of CE in subjects with pedophilia with (P+CSO) and without (P-CSO) child sexual offending. 15 P+CSO, 15 P-CSO, and 24 teleiophilic male controls (TC) performed a CE task during fMRI. We observed reduced activation in the left precuneus (Pcu) and increased activation in the left anterior cingulate cortex (ACC) in P-CSO compared to P+CSO. P-CSO also showed stronger connectivity between these regions, which might reflect a top-down modulation of the Pcu by the ACC toward an increased self-focused emotional reaction in social situations. There was also evidence for increased right superior temporal gyrus activation in P-CSO that might constitute a potentially compensatory recruitment due to the dampened Pcu activation. These findings provide first evidence for altered neural processing of CE in P-CSO and underline the importance of addressing CE in pedophilia and CSO in order to uncover processes relevant to effective prevention of child sexual abuse.

Touched by Loneliness – How Loneliness Impacts the Response to Observed Human Touch: a tDCS Study

Lonely people often crave connectedness. However, they may also experience their environment as threatening, entering a self-preserving state that perpetuates loneliness. Research shows conflicting evidence about their response to positive social cues, and little is known about their experience of observed human touch. The right inferior frontal gyrus (rIFG) is part of an observation-execution network implicated in observed touch perception. Correlative studies also point to rIFG’s involvement in loneliness. We examined the causal effect of rIFG anodal transcranial direct current stimulation (tDCS) on high and low loneliness individuals observing human touch. In a cross-over design study, 40 participants watched pictures of humans or objects touching or not touching during anodal and sham stimulations. Participants indicated whether pictures contained humans or objects and their reaction time was measured. Results show that the reaction time of low loneliness individuals to observed human touch was significantly slower during anodal stimulation compared to high loneliness individuals, possibly due to them being more emotionally distracted by it. Lonely individuals also reported less liking of touch. Our findings support the notion that lonely individuals are not drawn to positive social cues. This may help explain the perpetuation of loneliness, despite social opportunities that could be available to lonely people.

A Multidimensional Examination of Psychopathy Traits and Gray Matter Volume in Adults

Uncovering the neurobiological abnormalities that may contribute to the manifestation of psychopathic traits is an important step towards understanding the etiology of this disorder. Although many studies have examined gray matter volume (GMV) in relation to psychopathy, few have examined how dimensions of psychopathic traits interactively relate to GMV, an approach that holds promise for parsing heterogeneity in neurobiological risk factors for this disorder. The aim of this study was to investigate the affective-interpersonal (Factor 1) and impulsive-antisocial (Factor 2) dimensions of psychopathy in relation to cortical surface and subcortical GMV in a mixed-gender, high-risk community sample with significant justice-system involvement (N = 156, 50.0% men). Cortex-wide analysis indicated that (i) the Factor 1 traits correlated negatively with GMV in two cortical clusters, one in the right rostral middle frontal region and one in the occipital lobe, and (ii) the interaction of the affective-interpersonal and impulsive-antisocial traits was negatively associated with GMV bilaterally in the parietal lobe, such that individuals high on both trait dimensions evidenced reduced GMV relative to individuals high on only one psychopathy factor. An interactive effect also emerged for bilateral amygdalar and hippocampal GMV, such that Factor 1 psychopathic traits were significantly negatively associated with GMV only at high (but not low) levels of Factor 2 traits. Results extend prior research by demonstrating the neurobiological correlates of psychopathy differ based on the presentation of Factor 1 and 2 traits.

Maladaptive Self-Focused Attention and Default Mode Network Connectivity: A Transdiagnostic Investigation Across Social Anxiety and Body Dysmorphic Disorders

Maladaptive self-focused attention (SFA) is a bias toward internal thoughts, feelings, and physical states. Despite its role as a core maintaining factor of symptoms in cognitive theories of social anxiety and body dysmorphic disorders, studies have not examined its neural basis. In this study, we hypothesized that maladaptive SFA would be associated with hyperconnectivity in the default mode network (DMN) in self-focused patients with these disorders. Thirty patients with primary social anxiety disorder or primary body dysmorphic disorder, and 28 healthy individuals were eligible and scanned. Eligibility was determined by scoring greater than 1SD or below 1SD of the Public Self-Consciousness Scale normative mean, respectively, for each group. Seed-to-voxel functional connectivity was computed using a DMN posterior cingulate cortex (PCC) seed. There was no evidence of increased DMN functional connectivity in patients compared to controls. Patients (regardless of diagnosis) showed reduced functional connectivity of the PCC with several brain regions, including the bilateral superior parietal lobule (SPL), compared to controls, which was inversely correlated with maladaptive SFA but not associated with social anxiety, body dysmorphic, or depression severity, or rumination. Abnormal PCC-SPL connectivity may represent a transdiagnostic neural marker of SFA that reflects difficulty shifting between internal versus external attention.

Early and late neural correlates of mentalizing: ALE meta-analyses in adults, children and adolescents

The ability to understand mental states of others is referred to as mentalizing and enabled by our Theory of Mind. This social skill relies on brain regions comprising the mentalizing network as robustly observed in adults but also in a growing number of developmental studies. We summarized and compared neuroimaging evidence in children/adolescents and adults during mentalizing using coordinate-based activation likelihood estimation meta-analyses to inform about brain regions consistently or differentially engaged across age categories. Adults (N = 5286) recruited medial prefrontal and middle/inferior frontal cortices, precuneus, temporoparietal junction and middle temporal gyri during mentalizing, which were functionally connected to bilateral inferior/superior parietal lobule and thalamus/striatum. Conjunction and contrast analyses revealed that children and adolescents (N = 479) recruit similar but fewer regions within core mentalizing regions. Subgroup analyses revealed an early continuous engagement of middle medial prefrontal cortex, precuneus and right temporoparietal junction in younger children (8–11 years) and adolescents (12–18 years). Adolescents additionally recruited the left temporoparietal junction and middle/inferior temporal cortex. Overall, the observed engagement of the medial prefrontal cortex, precuneus and right temporoparietal junction during mentalizing across all ages reflects an early specialization of some key regions of the social brain.

Neural rhythmic underpinnings of intergroup bias: implications for peace-building attitudes and dialogue

Intergroup bias is a ubiquitous socio-cognitive phenomenon that, while sustaining human dependence on group living, often leads to prejudice, inequity, and violence; yet, its neural underpinnings remain unclear. Framed within the Israeli–Palestinian conflict and targeting youth, this study utilized magnetoencephalography to describe intrinsic neural oscillatory processes that represent the intergroup bias and may link with engagement in peacemaking in order to shed further light on the neural mechanisms underpinning intergroup conflict. Across the oscillatory spectrum, from very low to very high frequency bands, the only rhythm found to underlie the intergroup bias was the alpha rhythm. Alpha rhythm was continuously activated across the task and integrated a rapid perceptual component in the occipital cortex with a top-down cognitive-control component in the medial cingulate cortex. These components were distinctly associated with the real-life intergroup dialogue style and expressed attitudes that promote active engagement in peacemaking. Our findings suggest that the cortical alpha rhythm plays a crucial role in sustaining intergroup bias and addresses its impact on concrete intergroup experiences. The results highlight the need to provide opportunities for active peace-building dialogue to youth reared amidst intractable conflicts.

Neuro-computational foundations of moral preferences

Moral preferences pervade many aspects of our lives, dictating how we ought to behave, whom we can marry and even what we eat. Despite their relevance, one fundamental question remains unanswered: where do individual moral preferences come from? It is often thought that all types of preferences reflect properties of domain-general neural decision mechanisms that employ a common ‘neural currency’ to value choice options in many different contexts. This view, however, appears at odds with the observation that many humans consider it intuitively wrong to employ the same scale to compare moral value (e.g. of a human life) with material value (e.g. of money). In this paper, we directly test if moral subjective values are represented by similar neural processes as financial subjective values. In a study combining functional magnetic resonance imaging with a novel behavioral paradigm, we identify neural representations of the subjective values of human lives or financial payoffs by means of structurally identical computational models. Correlating isomorphic model variables from both domains with brain activity reveals specific patterns of neural activity that selectively represent values in the moral (right temporo-parietal junction) or financial (ventral-medial prefrontal cortex) domain. Intriguingly, our findings show that human lives and money are valued in (at least partially) distinct neural currencies, supporting theoretical proposals that human moral behavior is guided by processes that are distinct from those underlying behavior driven by personal material benefit.