Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial

2015 ◽  
Vol 53 (5) ◽  
pp. 416-420 ◽  
Author(s):  
P. Xue ◽  
J. Wang ◽  
B. Wu ◽  
Y. Ma ◽  
F. Wu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Antibiotic Prophylaxis ◽  
Chinese Patients ◽  
Controlled Clinical Trial ◽  
Third Molars ◽  
Double Blind ◽  
Impacted Mandibular Third Molars ◽  
Postoperative Inflammatory Complications ◽  
Mandibular Third Molars

scholarly journals Efficacy of Submucosal Injection of Chymotrypsin, Oral Serratiopeptidase or Oral Dexamethasone in Reducing Postoperative Complications Following Impacted Lower Third Molar Surgery: A Prospective, Randomized, Double-Blind, Controlled Clinical Trial

2020 ◽  
Vol 1 ◽  
Author(s):  
Essam Ahmed Al-Moraissi ◽  
Elham Aziz Al-Zendani ◽  
Abeer Mohammed Al-Selwi
Keyword(s):  
Clinical Trial ◽  
Postoperative Complications ◽  
Mouth Opening ◽  
Third Molars ◽  
Double Blind ◽  
Oral Dexamethasone ◽  
Facial Swelling ◽  
Maximal Mouth Opening ◽  
Impacted Mandibular Third Molars ◽  
Mandibular Third Molars

Aim The study aimed to compare between chymotrypsin, oral serratiopeptidase, and oral dexamethasone following impacted mandibular third molars surgery in respect of postoperative complications.Materials and method: A randomized, double-blind clinical trial was conducted on 60 patients who were candidates for impacted mandibular third molars surgery and randomly allocated into the following 3 groups: submucosal chymotrypsin (5 mg), oral serratiopeptidase (10 mg), and oral dexamethasone (8 mg) (each group = 20). The outcome variables were postoperative pain (via visual analog scale), facial swelling (via tape method) and maximal mouth opening immediately after 2nd, 3rd, and 5th postoperative days.Results: A total of 60 patients underwent randomization and allocation concealment and were included in the current study. All of the subjects tolerated the medicines with no untoward side or adverse effects. There was no statistically significant difference between the three groups in respect of postoperative pain intensity, facial swelling and maximal mouth opening at the immediate first hour, 2nd, 3rd, and 5th postoperative days (P < 0.05).Conclusion: The present randomized clinical trial concluded that preemptive sub-mucosal injection of chymotrypsin yields a comparable effectiveness in decreasing postoperative sequelae following impacted mandibular third molars surgery when compared to oral serratiopeptidase or dexamethasone. This is the first Randomized Clinical Trail that assessed efficacy and safety of sub-mucosal injection of chymotrypsin after impacted mandibular third molars surgery. This trial is registered at clinicaltrials.in.th, number (TCTR20200828006).

Sign in / Sign up

Export Citation Format

Share Document