SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.05.040 ◽

2009 ◽

Vol 17 (14) ◽

pp. 5247-5258 ◽

Author(s):

Simon N. Haydar ◽

Chiara Ghiron ◽

Laura Bettinetti ◽

Hendrick Bothmann ◽

Thomas A. Comery ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Biological Evaluation ◽

Nicotinic Acetylcholine ◽

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Corrigendum to “SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist” [Bioorg. Med. Chem. 17 (2009) 5247]

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.11.042 ◽

2010 ◽

Vol 18 (2) ◽

pp. 985

Author(s):

Simon N. Haydar ◽

Chiara Ghiron ◽

Laura Bettinetti ◽

Hendrick Bothmann ◽

Thomas A. Comery ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Biological Evaluation ◽

Nicotinic Acetylcholine ◽

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P4-310: Preclinical characterization of a selective alpha-7 neuronal nicotinic acetylcholine receptor agonist ABT-126: A novel therapeutic agent for the treatment of cognitive impairment in Alzheimer's disease and schizophrenia

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.1755 ◽

2013 ◽

Vol 9 ◽

pp. P817-P818 ◽

Author(s):

Robert Bitner ◽

David Anderson ◽

Karla Drescher ◽

Kathy Kohlhaas ◽

Halvard Gronlien ◽

...

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Therapeutic Agent ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Alpha 7 ◽

Novel Therapeutic

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Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture

Journal of Neurochemistry ◽

10.1111/jnc.12817 ◽

2014 ◽

Vol 131 (4) ◽

pp. 498-508 ◽

Author(s):

Zhenying Han ◽

Li Li ◽

Liang Wang ◽

Vincent Degos ◽

Mervyn Maze ◽

...

Keyword(s):

Oxidative Stress ◽

Ischemic Stroke ◽

Brain Injury ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Bone Fracture ◽

Receptor Agonist ◽

Nicotinic Acetylcholine ◽

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Alpha 7 nicotinic acetylcholine receptor agonist GTS-21 mitigates isoflurane-induced cognitive impairment in aged rats

Journal of Surgical Research ◽

10.1016/j.jss.2014.09.043 ◽

2015 ◽

Vol 194 (1) ◽

pp. 255-261 ◽

Author(s):

Fei-Juan Kong ◽

Lei-Lei Ma ◽

Hong-Hai Zhang ◽

Jia-Qiang Zhou

Keyword(s):

Cognitive Impairment ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Aged Rats ◽

Nicotinic Acetylcholine ◽

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High-Fat Diet-Induced Neuropathy of the Enteric Nervous System and the Effect of Alpha-7 Nicotinic Acetylcholine Receptor Agonist, DMAB-Anabaseine Dihydrochloride

Gastroenterology ◽

10.1016/s0016-5085(11)62251-8 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-544

Author(s):

Onesmo B. Balemba ◽

Chloe M. Stenkamp-Strahm ◽

Joshua Cady ◽

Ailene MacPherson

Keyword(s):

Nervous System ◽

Enteric Nervous System ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

High Fat Diet ◽

Receptor Agonist ◽

High Fat ◽

Nicotinic Acetylcholine ◽

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Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)

Journal of Medicinal Chemistry ◽

10.1021/jm300247y ◽

2012 ◽

Vol 55 (10) ◽

pp. 4806-4823 ◽

Author(s):

Riccardo Zanaletti ◽

Laura Bettinetti ◽

Cristiana Castaldo ◽

Giuseppe Cocconcelli ◽

Thomas Comery ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Pentanoic Acid ◽

Nicotinic Acetylcholine ◽

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Protective effect of an alpha 7 nicotinic acetylcholine receptor agonist against enterovirus 71 infection in neuronal cells

Antiviral Research ◽

10.1016/j.antiviral.2017.10.007 ◽

2018 ◽

Vol 149 ◽

pp. 106-112 ◽

Author(s):

Feng Xia Song ◽

Lin Qing Zhao ◽

Ru Nan Zhu ◽

Qin Wei Song ◽

Jie Deng ◽

...

Keyword(s):

Protective Effect ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Neuronal Cells ◽

Enterovirus 71 ◽

Nicotinic Acetylcholine ◽

Alpha 7 ◽

Enterovirus 71 Infection

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Alpha-7 nicotinic acetylcholine receptor agonist treatment in a rat model of Huntington's disease and involvement of heme oxygenase-1

Neural Regeneration Research ◽

10.4103/1673-5374.230301 ◽

2018 ◽

Vol 13 (4) ◽

pp. 737 ◽

Author(s):

Laura Foucault-Fruchard ◽

Claire Tronel ◽

Sylvie Bodard ◽

Zuhal Gulhan ◽

Julie Busson ◽

...

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Heme Oxygenase ◽

Rat Model ◽

Receptor Agonist ◽

Heme Oxygenase 1 ◽

Nicotinic Acetylcholine ◽

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Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons

Brain Research ◽

10.1016/s0006-8993(01)03028-1 ◽

2001 ◽

Vol 919 (1) ◽

pp. 166-168 ◽

Author(s):

Xu-Feng Zhang ◽

David G. McKenna ◽

Clark A. Briggs

Keyword(s):

Dorsal Root Ganglion ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Dorsal Root ◽

Receptor Agonist ◽

Dorsal Root Ganglion Neurons ◽

Nicotinic Acetylcholine ◽

Ganglion Neurons

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Protein-ligand interactions. 6 nicotinic acetylcholine receptor agonist activity of isoquinoline alkaloids

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(96)00429-5 ◽

1996 ◽

Vol 6 (23) ◽

pp. 2801-2806 ◽

Author(s):

C.G. Whiteley ◽

S. Daya

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Agonist ◽

Agonist Activity ◽

Isoquinoline Alkaloids ◽

Nicotinic Acetylcholine ◽

Protein Ligand Interactions ◽

Ligand Interactions

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