scholarly journals Natural product leads for drug discovery: Isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents

2009 ◽  
Vol 17 (20) ◽  
pp. 7126-7130 ◽  
Author(s):  
Songpo Guo ◽  
Suresh K. Tipparaju ◽  
Scott D. Pegan ◽  
Baojie Wan ◽  
Shunyan Mo ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Natural Product ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of truncated derivatives of abyssomicin C as antibacterial agents

2019 ◽  
Vol 15 ◽  
pp. 1468-1474
Author(s):  
Leticia Monjas ◽  
Peter Fodran ◽  
Johanna Kollback ◽  
Carlo Cassani ◽  
Thomas Olsson ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Natural Product ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Methicillin Resistant ◽  
Structure Activity ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of ◽  
Novel Antibiotics

The synthesis and antibacterial activity of two new highly truncated derivatives of the natural product abyssomicin C are reported. This work outlines the limits of structural truncation of the natural product and consequently provides insights for further structure–activity relationship studies towards novel antibiotics targeting 4-amino-4-deoxychorismate (ADC) synthase. Specifically, it is demonstrated that the synthetically challenging bicyclic motif is essential for activity towards methicillin-resistant Staphylococcus aureus (MRSA).

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Synthesis and Biological Evaluation of a New Series of Benzothiazole-Quinolone Hybrids as Antibacterial Agents

2008 ◽  
Vol 5 (5) ◽  
pp. 353-357 ◽  
Author(s):  
Ahmed Kamal ◽  
S. Ahmed ◽  
M. A. Khan ◽  
Rajesh Shetty ◽  
B. Siddhardha ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of Fingolimod Derivatives as Antibacterial Agents

ACS Omega ◽  
2021 ◽  
Author(s):  
Matej Zore ◽  
Shella Gilbert-Girard ◽  
Inés Reigada ◽  
Jayendra Z. Patel ◽  
Kirsi Savijoki ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents

RSC Advances ◽  
2020 ◽  
Vol 10 (50) ◽  
pp. 30223-30237
Author(s):  
Prasanta Das ◽  
Sarah Boone ◽  
Dipanwita Mitra ◽  
Lindsay Turner ◽  
Ritesh Tandon ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Biological Evaluation ◽  
Biological Relevance ◽  
Anti Cancer ◽  
Synthesis And Biological Evaluation

The synthetic efficacy and biological relevance extend an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.

Synthesis and Biological Evaluation of 8-Aminomethyltetracycline Derivatives as Novel Antibacterial Agents

2013 ◽  
Vol 56 (20) ◽  
pp. 8112-8138 ◽  
Author(s):  
Roger B. Clark ◽  
Minsheng He ◽  
Yonghong Deng ◽  
Cuixiang Sun ◽  
Chi-Li Chen ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of acylated oligorhamnoside derivatives structurally related to mezzettiaside-6 with cytotoxic activity

2016 ◽  
Vol 14 (28) ◽  
pp. 6691-6702 ◽  
Author(s):  
Gaopeng Song ◽  
Sumei Li ◽  
Zhiwei Lei ◽  
Yibin Li ◽  
Junhua Li ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Natural Product ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Two partially acylated oligorhamnoside derivatives 1 and 2 structurally related to the natural product mezzettiaside-6 were synthesized via a ‘2 + 1 + 1’ convergent strategy.

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