Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A
Keyword(s):
The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.
2018 ◽
2007 ◽
Vol 50
(19)
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pp. 4561-4571
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2013 ◽
Vol 23
(4)
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pp. 1013-1016
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2018 ◽
Vol 15
(8)
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pp. 905-912
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Keyword(s):
2006 ◽
Vol 16
(18)
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pp. 4804-4807
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