Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity

2013 ◽  
Vol 21 (7) ◽  
pp. 1661-1670 ◽  
Author(s):  
Ahmed O.H. El-Nezhawy ◽  
Ayman R. Biuomy ◽  
Fatma S. Hassan ◽  
Ayman K. Ismaiel ◽  
Hany A. Omar
Keyword(s):  
Inflammatory Activity ◽  
Design Synthesis ◽  
Pharmacological Evaluation ◽  
Anti Inflammatory

scholarly journals Design, Synthesis and Anti-inflammatory Activity of Structurally Simple Anthranilic Acid Congeners Devoid of Ulcerogenic Side Effects

2012 ◽  
Vol 60 (10) ◽  
pp. 1290-1300 ◽  
Author(s):  
Amal Abdel Haleem Mohamed Eissa ◽  
Gamal Abd El-Hakeem Soliman ◽  
Moayad Hussein Khataibeh
Keyword(s):  
Side Effects ◽  
Anthranilic Acid ◽  
Inflammatory Activity ◽  
Design Synthesis ◽  
Anti Inflammatory

scholarly journals Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Musab Mohamed Ibrahim ◽  
Tilal Elsaman ◽  
Mosab Yahya Al-Nour
Keyword(s):  
Virtual Screening ◽  
Condensation Reaction ◽  
Docking Study ◽  
Positive Control ◽  
Inflammatory Activity ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Chemical Structures ◽  
Anti Inflammatory

The design, synthesis, and development of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are respectable area of research. Novel Diclofenac Schiff’s bases (M1, M2, M4, M7, and M8) were designed and synthesized, and their respective chemical structures were deduced using various spectral tools (IR, 1H NMR, 13C NMR, and MS). The compounds were synthesized via Schiff’s condensation reaction and their anti-inflammatory activity was investigated applying the Carrageenan-induced paw edema model against Diclofenac as positive control. Percentage inhibition of edema indicated that all compounds were exhibiting a comparable anti-inflammatory activity as Diclofenac. Moreover, the anti-inflammatory activity was supported via virtual screening using molecular docking study. Interestingly compound M2 showed the highest in vivo activity (61.32% inhibition) when compared to standard Diclofenac (51.36% inhibition) as well as the best binding energy score (-10.765) and the virtual screening docking score (-12.142).

scholarly journals Synthesis and pharmacological evaluation of marine bromopyrrole alkaloid-based hybrids with anti-inflammatory activity

2017 ◽  
Vol 10 (4) ◽  
pp. 458-464 ◽  
Author(s):  
Rajesh A. Rane ◽  
Mukesh Nandave ◽  
Suresh Nayak ◽  
Anushri Naik ◽  
Dhwani Shah ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Pharmacological Evaluation ◽  
Anti Inflammatory

scholarly journals Design, synthesis and pharmacological evaluation of new anti-inflammatory compounds

2016 ◽  
Vol 791 ◽  
pp. 195-204 ◽  
Author(s):  
Amanda F. Cidade ◽  
Patrícia A. Vasconcelos ◽  
Daiany P.B. Silva ◽  
Iziara F. Florentino ◽  
Géssica A. Vasconcelos ◽  
...  
Keyword(s):  
Design Synthesis ◽  
Pharmacological Evaluation ◽  
Anti Inflammatory
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