Discovery and mechanistic study of thiazole-4-acylsulfonamide derivatives as potent and orally active ChemR23 inhibitors with a long-acting effect in cynomolgus monkeys

Development of bambuterol; a long acting, orally active beta-agonist prodrug

Treatment of Asthma: The long-acting beta-2-agonists ◽

10.1007/978-3-7091-7513-2_5 ◽

1998 ◽

pp. 71-90

Author(s):

Leif-Ake Svensson

Keyword(s):

Beta Agonist ◽

Long Acting ◽

Discovery of an Orally Active and Long‐Acting DPP‐IV Inhibitor through Property‐Based Optimization with an in Silico Biotransformation Prediction Tool

ChemMedChem ◽

10.1002/cmdc.202000175 ◽

2020 ◽

Vol 15 (16) ◽

pp. 1608-1617

Author(s):

Shaogao Zeng ◽

Wenyuan Dou ◽

Manna Li ◽

Yang Zhou ◽

Jiehuang Guo ◽

...

Keyword(s):

In Silico ◽

Prediction Tool ◽

Dpp Iv ◽

Long Acting ◽

Orally Active Non-Peptide Fibrinogen Receptor (GpIIb/IIIa) Antagonists: Identification of 4-[4-[4-(Aminoimino methyl)phenyl]-1-piperazinyl]-1- piperidineacetic Acid as a Long-Acting, Broad-Spectrum Antithrombotic Agent

10.1021/jm00049a006 ◽

1994 ◽

Vol 37 (23) ◽

pp. 3882-3885 ◽

Cited By ~ 27

Author(s):

Colin D. Eldred ◽

Brian Evans ◽

Sean Hindley ◽

Brian D. Judkins ◽

Henry A. Kelly ◽

...

Keyword(s):

Broad Spectrum ◽

Antithrombotic Agent ◽

Fibrinogen Receptor ◽

Long Acting ◽

Orally Active ◽

Methyl Phenyl

Discovery and Preclinical Profile of Saxagliptin (BMS-477118): A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

10.1021/jm050261p ◽

2005 ◽

Vol 48 (15) ◽

pp. 5025-5037 ◽

Cited By ~ 418

Author(s):

David J. Augeri ◽

Jeffrey A. Robl ◽

David A. Betebenner ◽

David R. Magnin ◽

Ashish Khanna ◽

...

Keyword(s):

Type 2 Diabetes ◽

Dipeptidyl Peptidase ◽

Dipeptidyl Peptidase Iv ◽

Long Acting ◽

ChemInform Abstract: A Potent, Long-Acting, Orally Active (2R)-2-[(1R)-3,3-Difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: A Novel Muscarinic M3 Receptor Antagonist with High Selectivity for M3 over M2 Receptors.

ChemInform ◽

10.1002/chin.200113139 ◽

2001 ◽

Vol 32 (13) ◽

pp. no-no

Author(s):

Norikazu Ohtake ◽

Toshiaki Mase ◽

et al. et al.

Keyword(s):

Receptor Antagonist ◽

High Selectivity ◽

M3 Receptor ◽

Long Acting ◽

A small molecule compound berberine as an orally active therapeutic candidate against COVID‐19 and SARS: A computational and mechanistic study

The FASEB Journal ◽

10.1096/fj.202001792r ◽

2021 ◽

Vol 35 (4) ◽

Author(s):

Zhen‐Zhen Wang ◽

Kun Li ◽

Anish R. Maskey ◽

Weihua Huang ◽

Anton A. Toutov ◽

...

Keyword(s):

Small Molecule ◽

Mechanistic Study ◽

Small Molecule Compound ◽

Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys

10.1021/acs.jmedchem.5b00851 ◽

2015 ◽

Vol 58 (20) ◽

pp. 8054-8065 ◽

Cited By ~ 24

Author(s):

Rainer E. Martin ◽

Johannes D. Aebi ◽

Benoit Hornsperger ◽

Hans-Jakob Krebs ◽

Bernd Kuhn ◽

...

Keyword(s):

In Vivo Evaluation ◽

Aldosterone Synthase ◽

Cynomolgus Monkeys ◽

Non-Peptide Glycoprotein IIb/IIIa Inhibitors. 17. Design and Synthesis of Orally Active, Long-Acting Non-Peptide Fibrinogen Receptor Antagonists

10.1021/jm9608117 ◽

1997 ◽

Vol 40 (12) ◽

pp. 1779-1788 ◽

Cited By ~ 40

Author(s):

Benny C. Askew ◽

Rodney A. Bednar ◽

Bohumil Bednar ◽

David A. Claremon ◽

Jacquelynn J. Cook ◽

...

Keyword(s):

Receptor Antagonists ◽

Design And Synthesis ◽

Fibrinogen Receptor ◽

Long Acting ◽

3-30-17 Combined effects of long-acting D2 agonist, cabergoline and L-DOPA on parkinsonism in MPTP-treated cynomolgus monkeys

Journal of the Neurological Sciences ◽

10.1016/s0022-510x(97)85754-1 ◽

1997 ◽

Vol 150 ◽

pp. S182 ◽

Cited By ~ 1

Author(s):

S. Kuno ◽

E. Mizuta ◽

N. Arai ◽

M. Isaji ◽

A. Ujiie

Keyword(s):

Combined Effects ◽

Cynomolgus Monkeys ◽

D2 Agonist ◽

Long Acting

Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics

10.1021/jm101597x ◽

2011 ◽

Vol 54 (8) ◽

pp. 2805-2822 ◽

Cited By ~ 42

Author(s):

Cyrine Ezzili ◽

Mauro Mileni ◽

Nicholas McGlinchey ◽

Jonathan Z. Long ◽

Steven G. Kinsey ◽

...

Keyword(s):

Fatty Acid ◽

Fatty Acid Amide Hydrolase ◽

Acid Amide ◽

Side Chain ◽

Conformational Constraints ◽

Acyl Side Chain ◽

Amide Hydrolase ◽

Long Acting ◽

Orally Active ◽

Fatty Acid Amide