Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator

2004 ◽  
Vol 14 (16) ◽  
pp. 4179-4183 ◽  
Author(s):  
Noah Tu ◽  
J.T Link ◽  
Bryan K Sorensen ◽  
Maurice Emery ◽  
Marlena Grynfarb ◽  
...  
Keyword(s):  
Bile Acid ◽  
Glucocorticoid Receptor ◽  
Receptor Modulator

The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice

2014 ◽  
Vol 143 ◽  
pp. 40-48 ◽  
Author(s):  
Maria Meyer ◽  
Maria Claudia Gonzalez Deniselle ◽  
Hazel Hunt ◽  
E. Ronald de Kloet ◽  
Alejandro F. De Nicola
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Modulator

scholarly journals Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers

2019 ◽  
Vol Volume 13 ◽  
pp. 3845-3853
Author(s):  
Susanne Prothon ◽  
Ulrika Wählby Hamrén ◽  
Ulrika Tehler ◽  
Esther Yoon ◽  
Henrik Forsman ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Receptor Modulator

scholarly journals Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation

2016 ◽  
Vol 173 (11) ◽  
pp. 1793-1804 ◽  
Author(s):  
José K van den Heuvel ◽  
Mariëtte R Boon ◽  
Ingmar van Hengel ◽  
Emma Peschier-van der Put ◽  
Lianne van Beek ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Modulator ◽  
Diet Induced Obesity

scholarly journals Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor

2003 ◽  
Vol 124 (4) ◽  
pp. A104-A105
Author(s):  
Diana Jung ◽  
Amedeo C. Fantin ◽  
Ulrich Scheurer ◽  
Michael Fried ◽  
Gerd A. Kullak-Ublick
Keyword(s):  
Bile Acid ◽  
Glucocorticoid Receptor ◽  
Transporter Gene ◽  
Bile Acid Transporter ◽  
Acid Transporter

scholarly journals Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding

2020 ◽  
Author(s):  
Bojana R. Vasiljević ◽  
Edward T. Petri ◽  
Sofija S. Bekić ◽  
Andjelka S. Ćelić ◽  
Ljubica M. Grbović ◽  
...  
Keyword(s):  
Bile Acid ◽  
Microwave Irradiation ◽  
Glucocorticoid Receptor ◽  
Ligand Binding ◽  
Green Synthesis ◽  
Bile Acids ◽  
Receptor Binding ◽  
Microwave Assisted ◽  
Bile Acid Derivatives ◽  
Cholanic Acid

Green synthesis of bile acids derivatives and 5β-cholanic acid was achieved under microwave irradiation, and the binding affinity for the ligand binding domain of the glucocorticoid receptor was measured.

scholarly journals Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate

2020 ◽  
Vol 30 (16) ◽  
pp. 127298
Author(s):  
Markus Berger ◽  
Ekkehard May ◽  
Hartmut Rehwinkel ◽  
Heike Schäcke ◽  
Roland Neuhaus ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Modulator ◽  
Clinical Candidate
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