Novel peptide derivatives of bleomycin A5: Synthesis, antitumor activity and interaction with DNA

2005 ◽  
Vol 15 (18) ◽  
pp. 3996-3999 ◽  
Author(s):  
Zhi-Dong Xu ◽  
Min Wang ◽  
Su-Long Xiao ◽  
Ming Yang
Keyword(s):  
Antitumor Activity ◽  
Peptide Derivatives ◽  
Derivatives Of

Synthesis of New Peptide Derivatives of Galanthamine Designed for Prevention and Treatment of Alzheimer’s Disease

2015 ◽  
Vol 22 (10) ◽  
pp. 913-922 ◽  
Author(s):  
Lyubomir Vezenkov ◽  
Lilia Ilieva ◽  
Dancho Danalev ◽  
Anastasia Bakalova ◽  
D. Vassilev ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prevention And Treatment ◽  
Peptide Derivatives ◽  
Derivatives Of

ChemInform Abstract: SYNTHESIS AND ANTITUMOR ACTIVITY OF 6-OXO-7-AMINO DERIVATIVES OF 5H-PYRIDO(2,3B)- AND 5H-PYRIMIDO(4,5B)(1,4)THIAZINES

1985 ◽  
Vol 16 (15) ◽  
Author(s):  
N. I. TRAVEN' ◽  
YU. A. ERSHOVA ◽  
A. S. SOKOLOVA ◽  
V. A. CHERNOV ◽  
T. S. SAFONOVA
Keyword(s):  
Antitumor Activity ◽  
Amino Derivatives ◽  
Derivatives Of

Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

2014 ◽  
Vol 74 ◽  
pp. 742-750 ◽  
Author(s):  
Chengyuan Liang ◽  
Juan Xia ◽  
Dong Lei ◽  
Xiang Li ◽  
Qizheng Yao ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antitumor Activity ◽  
Schiff Base Derivatives ◽  
In Vivo Antitumor Activity ◽  
Derivatives Of

scholarly journals Preparation and Antitumor Activity of 2''-O-,3''-O-and 2'',3''-Di-O-substituted Derivatives of Etoposide.

1992 ◽  
Vol 40 (7) ◽  
pp. 1783-1788 ◽  
Author(s):  
Takeshi OHNUMA ◽  
Rika OBATA ◽  
Yuji NISHIYAMA ◽  
Tetsuro YAMASAKI ◽  
Hideo KAMEI ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Derivatives Of

The Preparation and Antitumor Activity of Certain Derivatives of 6-Mercaptopurine

1962 ◽  
Vol 5 (3) ◽  
pp. 607-617 ◽  
Author(s):  
Leland R. Lewis ◽  
C. Wayne. Noell ◽  
Alden G. Beaman ◽  
Roland K. Robins
Keyword(s):  
Antitumor Activity ◽  
Derivatives Of

STUDY OF THE BIOLOGICAL PROPERTIES OF SEMI- AND THIOSEMICARBAZONES OF CARBONYL DERIVATIVES OF 4-BUTANOLIDES

2021 ◽  
Vol 55 (2 (255)) ◽  
pp. 103-111
Author(s):  
Tariel V. Ghochikyan ◽  
Armen S. Galstyan ◽  
Hrachik M. Stepanyan ◽  
Irina G. Korpakova ◽  
Alexander S. Kinzirsky
Keyword(s):  
Antitumor Activity ◽  
Green Alga ◽  
Biological Properties ◽  
Lymphocytic Leukemia ◽  
Thiazole Ring ◽  
Lewis Lung ◽  
Ehrlich's Ascites Tumor ◽  
Carbonyl Derivatives ◽  
Derivatives Of ◽  
Test Objects

Based on carbonyl derivatives of 4-substituted-4-butanolides, the appropriate semi- and thiosemicarbazones have been synthesized. It has been found that some representatives of thiosemicarbazones have pronounced algicidal activity against filamentous green alga Cladophora and blue-green alga (cyanobacterium) Synechocystis and some of the semi- and thiosemicarbazones exhibit moderate antitumor activity. The assessment of the antitumor activity of the compounds was carried out using strains of syngeneic and allogeneic tumor systems as test-objects: lymphocytic leukemia P-388, Lewis lung carcinoma, B16 melanoma and Ehrlich’s ascites tumor. It has also been established that some representatives of thiosemi­carbazones exhibit antimutagenic properties. It has been reliably proven that with the formation of a thiazole ring, all properties disappear and a new property in the series of thiazololactones is revealed – antibacterial․

scholarly journals SYNTHESIS AND ANTIMICROBIAL EVALUATION OF QUINAZOLINONE PEPTIDE DERIVATIVES

2017 ◽  
Vol 10 (16) ◽  
pp. 7 ◽  
Author(s):  
Bhupinder Kapoor ◽  
Arshid Nabi ◽  
Reena Gupta ◽  
Mukta Gupta
Keyword(s):  
Antibacterial Activity ◽  
Amino Acid ◽  
Antimicrobial Agents ◽  
Methyl Esters ◽  
Standard Drug ◽  
Amino Acid Peptide ◽  
Chemical Structures ◽  
1H Nuclear Magnetic Resonance ◽  
Peptide Derivatives ◽  
Derivatives Of

  Objective: The increased microbial resistance against commercially available drugs initiated the development of novel and safe antimicrobial agents in last few decades. In this view, a series of amino acid/dipeptide derivatives of quinazolin-3(4H)-one was synthesized and was evaluated for their antimicrobial potential.Method: Synthesis of amino acid/peptide derivatives were carried out by coupling 5-(2-(2-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)-2-hydroxy benzoic acid with amino acid/dipeptide methyl esters in the presence of dicyclohexylcarbodiimide and N-methylmorpholine. The chemical structures of synthesized compounds were characterized by 1H nuclear magnetic resonance and infrared spectroscopy and were screened for antibacterial activity by disc diffusion method.Results: All the synthesized derivatives exhibited moderate to significant antibacterial activity against both Gram-positive and Gram-negative bacteria. The potency of compound 5d was comparable to standard drug ciprofloxacin in all the strains of bacteria used. The compound 5a was found to be more active against Streptococcus pyogenes and Staphylococcus aureus while compound 5c against Pseudomonas aeruginosa and Escherichia coli. Conclusion: Peptide derivatives of quinazolinone are promising antimicrobial agent and can be used for the synthesis of other novel compounds.

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