scholarly journals Synthesis and structure–activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors

2007 ◽  
Vol 17 (23) ◽  
pp. 6463-6466 ◽  
Author(s):  
Kateřina Čapková ◽  
Yoshiyuki Yoneda ◽  
Tobin J. Dickerson ◽  
Kim D. Janda
Keyword(s):  
Protease Inhibitors ◽  
Botulinum Neurotoxin ◽  
Second Generation ◽  
Botulinum Neurotoxin A ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Identification of 3-hydroxy-1,2-dimethylpyridine-4(1H)-thione as a metal-binding motif for the inhibition of botulinum neurotoxin A

2020 ◽  
Author(s):  
Lucy Lin ◽  
Lewis D. Turner ◽  
Peter Šilhár ◽  
Sabine Pellett ◽  
Eric A. Johnson ◽  
...  
Keyword(s):  
Motor Neurons ◽  
Light Chain ◽  
Metal Binding ◽  
Botulinum Neurotoxin ◽  
Chain Structure ◽  
Binding Motif ◽  
Botulinum Neurotoxin A ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Metal Binding Motif

The 3,4-HOPTO pharmacophore was identified as an inhibitor of botulinum neurotoxin A light chain. Structure-activity relationships were explored, resulting in a compound that protects SNAP-25 cleavage in motor neurons.

scholarly journals Front Cover: Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2 (2/2021)

ChemMedChem ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. 301-301
Author(s):  
Armin Welker ◽  
Christian Kersten ◽  
Christin Müller ◽  
Ramakanth Madhugiri ◽  
Collin Zimmer ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Front Cover ◽  
Structure Activity Relationships ◽  
Structure Activity

ChemInform Abstract: Synthesis and Structure-Activity Relationships of CP-122,721, a Second-Generation NK-1 Receptor Antagonist.

ChemInform ◽  
2010 ◽  
Vol 29 (24) ◽  
pp. no-no
Author(s):  
T. J. ROSEN ◽  
K. J. COFFMAN ◽  
S. MCLEAN ◽  
R. T. CRAWFORD ◽  
D. K. BRYCE ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Second Generation ◽  
Structure Activity Relationships ◽  
Structure Activity

Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist

1998 ◽  
Vol 8 (3) ◽  
pp. 281-284 ◽  
Author(s):  
Terry J. Rosen ◽  
Karen J. Coffman ◽  
Stafford McLean ◽  
Rosemary T. Crawford ◽  
Dianne K. Bryce ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Second Generation ◽  
Structure Activity Relationships ◽  
Structure Activity

Nonpeptide Cyclic Cyanoguanidines as HIV-1 Protease Inhibitors:  Synthesis, Structure−Activity Relationships, and X-ray Crystal Structure Studies

1998 ◽  
Vol 41 (9) ◽  
pp. 1446-1455 ◽  
Author(s):  
Prabhakar K. Jadhav ◽  
Francis J. Woerner ◽  
Patrick Y. S. Lam ◽  
C. Nicholas Hodge ◽  
Charles J. Eyermann ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Protease Inhibitors ◽  
X Ray ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Hiv 1

scholarly journals Synthesis and Biological Evaluation of Botulinum Neurotoxin A Protease Inhibitors

2010 ◽  
Vol 53 (5) ◽  
pp. 2264-2276 ◽  
Author(s):  
Bing Li ◽  
Ramdas Pai ◽  
Steven C. Cardinale ◽  
Michelle M. Butler ◽  
Norton P. Peet ◽  
...  
Keyword(s):  
Protease Inhibitors ◽  
Botulinum Neurotoxin ◽  
Biological Evaluation ◽  
Botulinum Neurotoxin A ◽  
Synthesis And Biological Evaluation
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