2,4(5)-Diarylimidazoles: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2

2008 ◽  
Vol 18 (20) ◽  
pp. 5460-5462 ◽  
Author(s):  
Mirko Rivara ◽  
Aparna R. Baheti ◽  
Marco Fantini ◽  
Giuseppe Cocconcelli ◽  
Chiara Ghiron ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Biological Evaluation ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
New Class ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection

2016 ◽  
Vol 14 (36) ◽  
pp. 8457-8473 ◽  
Author(s):  
Satish Chandra Philkhana ◽  
Suneet Mehrotra ◽  
Thomas F. Murray ◽  
D. Srinivasa Reddy
Keyword(s):  
Total Synthesis ◽  
Sodium Channel ◽  
Biological Evaluation ◽  
Detailed Account ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Channel Inhibition ◽  
Synthesis And Biological Evaluation

A detailed account on total synthesis, analogue synthesis, biological evaluation and SAR of palmyrolide A macrocycles towards sodium channel inhibition is reported.

scholarly journals Functional and structural features of γ-zeathionins, a new class of sodium channel blockers

FEBS Letters ◽  
1998 ◽  
Vol 440 (3) ◽  
pp. 302-306 ◽  
Author(s):  
Christopher Kushmerick ◽  
Mariana de Souza Castro ◽  
Jáder Santos Cruz ◽  
Carlos Bloch ◽  
Paulo S.L. Beirão
Keyword(s):  
Sodium Channel ◽  
Structural Features ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
New Class

Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers

2006 ◽  
Vol 16 (5) ◽  
pp. 1358-1361 ◽  
Author(s):  
Dong Ok ◽  
Chunshi Li ◽  
Catherine Abbadie ◽  
John P. Felix ◽  
Michael H. Fisher ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
New Class

C2-Modified Sparteine Derivatives Are a New Class of Potentially Long-Acting Sodium Channel Blockers

ChemMedChem ◽  
2017 ◽  
Vol 12 (22) ◽  
pp. 1819-1822 ◽  
Author(s):  
Vaibhavkumar S. Gawali ◽  
Svilen Simeonov ◽  
Martina Drescher ◽  
Thomas Knott ◽  
Olaf Scheel ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
New Class ◽  
Long Acting

Reconsidering the role of selective sodium channel blockers in genetic generalized epilepsy

2021 ◽  
Author(s):  
Emanuele Cerulli Irelli ◽  
Alessandra Morano ◽  
Martina Fanella ◽  
Biagio Orlando ◽  
Enrico M Salamone ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Generalized Epilepsy

ChemInform Abstract: Substituted Biaryl Pyrazoles as Sodium Channel Blockers.

ChemInform ◽  
2010 ◽  
Vol 41 (52) ◽  
pp. no-no
Author(s):  
Sriram Tyagarajan ◽  
et al. et al.
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers
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