Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection

2016 ◽  
Vol 14 (36) ◽  
pp. 8457-8473 ◽  
Author(s):  
Satish Chandra Philkhana ◽  
Suneet Mehrotra ◽  
Thomas F. Murray ◽  
D. Srinivasa Reddy
Keyword(s):  
Total Synthesis ◽  
Sodium Channel ◽  
Biological Evaluation ◽  
Detailed Account ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Channel Inhibition ◽  
Synthesis And Biological Evaluation

A detailed account on total synthesis, analogue synthesis, biological evaluation and SAR of palmyrolide A macrocycles towards sodium channel inhibition is reported.

2,4(5)-Diarylimidazoles: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2

2008 ◽  
Vol 18 (20) ◽  
pp. 5460-5462 ◽  
Author(s):  
Mirko Rivara ◽  
Aparna R. Baheti ◽  
Marco Fantini ◽  
Giuseppe Cocconcelli ◽  
Chiara Ghiron ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Biological Evaluation ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
New Class ◽  
Synthesis And Biological Evaluation

Reconsidering the role of selective sodium channel blockers in genetic generalized epilepsy

2021 ◽  
Author(s):  
Emanuele Cerulli Irelli ◽  
Alessandra Morano ◽  
Martina Fanella ◽  
Biagio Orlando ◽  
Enrico M Salamone ◽  
...  
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers ◽  
Generalized Epilepsy

scholarly journals Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3224
Author(s):  
Leander Geske ◽  
Ulrich Kauhl ◽  
Mohamed E. M. Saeed ◽  
Anja Schüffler ◽  
Eckhard Thines ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Total Syntheses ◽  
Wittig Olefination ◽  
Starting Point ◽  
Perkin Reaction ◽  
Synthesis And Biological Evaluation

The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.

ChemInform Abstract: Substituted Biaryl Pyrazoles as Sodium Channel Blockers.

ChemInform ◽  
2010 ◽  
Vol 41 (52) ◽  
pp. no-no
Author(s):  
Sriram Tyagarajan ◽  
et al. et al.
Keyword(s):  
Sodium Channel ◽  
Channel Blockers ◽  
Sodium Channel Blockers

Total synthesis and biological evaluation of Wewakazole

2017 ◽  
Vol 33 (6) ◽  
pp. 890-894 ◽  
Author(s):  
Bohua Long ◽  
Jingzhao Zhang ◽  
Xueyan Wang ◽  
Xudong Tang ◽  
Zhengzhi Wu
Keyword(s):  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation
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