Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: Structure–activity relationships of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template

2009 ◽  
Vol 19 (7) ◽  
pp. 1986-1990 ◽  
Author(s):  
Diane B. Hauze ◽  
Murty V. Chengalvala ◽  
Joshua E. Cottom ◽  
Irene B. Feingold ◽  
Lloyd Garrick ◽  
...  
Keyword(s):  
Small Molecule ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Structure Activity Relationships ◽  
Receptor Structure ◽  
Structure Activity

Discovery of a Novel, Orally Active, Small Molecule Gonadotropin-Releasing Hormone (GnRH) Receptor Antagonist

2006 ◽  
Vol 49 (11) ◽  
pp. 3362-3367 ◽  
Author(s):  
Haitao Li ◽  
Kenna L. Anderes ◽  
Eugenia A. Kraynov ◽  
David R. Luthin ◽  
Quyen-Quyen Do ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Small Molecule ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Orally Active

scholarly journals Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone (GnRH) receptor

MedChemComm ◽  
2017 ◽  
Vol 8 (10) ◽  
pp. 1965-1969 ◽  
Author(s):  
Richard Fjellaksel ◽  
Marc Boomgaren ◽  
Rune Sundset ◽  
Ira H. Haraldsen ◽  
Jørn H. Hansen ◽  
...  
Keyword(s):  
Small Molecule ◽  
Hormone Receptor ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Synthesis And Characterization ◽  
Releasing Hormone ◽  
Gonadotropin Releasing Hormone Receptor

In this communication, we report the synthesis and characterization of a library of small molecule antagonists of the human gonadotropin releasing hormone receptor based upon the 2-(4-tert-butylphenyl)-4-piperazinyl-benzimidazole scaffold via Cu-catalysed azide alkyne cycloaddition.

scholarly journals Discovery of a Novel, Orally Active, Small Molecule Gonadotropin-Releasing Hormone (GnRH) Receptor Antagonist.

2006 ◽  
Vol 49 (19) ◽  
pp. 5849-5849 ◽  
Author(s):  
Haitao Li ◽  
Kenna L. Anderes ◽  
Eugenia A. Kraynov ◽  
David R. Luthin ◽  
Quyen-Quyen Do ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Small Molecule ◽  
Gnrh Receptor ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Orally Active

scholarly journals Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization

2021 ◽  
Vol 64 (6) ◽  
pp. 3299-3319
Author(s):  
Jean-Olivier Zirimwabagabo ◽  
Ameera B. A. Jailani ◽  
Paris Avgoustou ◽  
Matthew J. Tozer ◽  
Karl R. Gibson ◽  
...  
Keyword(s):  
Small Molecule ◽  
Structure Activity Relationships ◽  
Small Molecule Antagonist ◽  
Receptor Structure ◽  
Structure Activity

Investigation of Structure-Activity Relationships of Synthetic Anti-Gonadotropin Releasing Hormone Vaccine Candidates

ChemMedChem ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. 901-910 ◽  
Author(s):  
Chenghung Chang ◽  
Pegah Varamini ◽  
Ashwini Kumar Giddam ◽  
Friederike M. Mansfeld ◽  
Michael J. D'Occhio ◽  
...  
Keyword(s):  
Gonadotropin Releasing Hormone ◽  
Vaccine Candidates ◽  
Releasing Hormone ◽  
Structure Activity Relationships ◽  
Structure Activity
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