Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Ronghui Lin; Sigmond G. Johnson; Peter J. Connolly; Steven K. Wetter; Eva Binnun; Terry V. Hughes; William V. Murray; Niranjan B. Pandey; Sandra J. Moreno-Mazza; Mary Adams; Angel R. Fuentes-Pesquera; Steven A. Middleton

doi:10.1016/j.bmcl.2009.02.067

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.02.067 ◽

2009 ◽

Vol 19 (8) ◽

pp. 2333-2337 ◽

Cited By ~ 75

Author(s):

Ronghui Lin ◽

Sigmond G. Johnson ◽

Peter J. Connolly ◽

Steven K. Wetter ◽

Eva Binnun ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth ◽

Pyrimidine Analogues

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Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors from the Natural Origin: A Recent Perspective

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520615666150312100259 ◽

2015 ◽

Vol 15 (8) ◽

pp. 988-1011 ◽

Cited By ~ 3

Author(s):

Harun Patel ◽

Rajesh Rane ◽

Neeta Thapliyal ◽

Mahesh Palkar ◽

Mahamadhanif Shaikh ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Natural Origin ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth

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ChemInform Abstract: Synthesis of Novel Benzoxazinone Compounds as Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors.

ChemInform ◽

10.1002/chin.201301148 ◽

2013 ◽

Vol 44 (1) ◽

pp. no-no

Author(s):

Shaopeng Chen ◽

Xuemin Li ◽

Shengbiao Wan ◽

Tao Jiang

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth

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Safety and Tolerability of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors in Oncology

Drug Safety ◽

10.1007/s40264-018-0772-x ◽

2019 ◽

Vol 42 (2) ◽

pp. 181-198 ◽

Cited By ~ 15

Author(s):

Rashmi R. Shah ◽

Devron R. Shah

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth

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Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidence

Critical Reviews in Oncology/Hematology ◽

10.1016/j.critrevonc.2011.11.010 ◽

2012 ◽

Vol 83 (3) ◽

pp. 407-421 ◽

Cited By ~ 94

Author(s):

Sai-Hong Ignatius Ou

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Clinical Evidence ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth

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Pharmacogenomics of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer ◽

10.1016/j.bbcan.2006.08.008 ◽

2006 ◽

Vol 1766 (2) ◽

pp. 217-229 ◽

Cited By ~ 10

Author(s):

Antonio Jimeno ◽

Manuel Hidalgo

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth

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Clinical Development of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors: What Lessons Have We Learned?

Advances in Experimental Medicine and Biology - Targeted Therapies in Cancer ◽

10.1007/978-0-387-73898-7_10 ◽

2008 ◽

pp. 128-143 ◽

Cited By ~ 2

Author(s):

Manuel Hidalgo

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Clinical Development ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth

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MET overexpression coexisting with epidermal growth factor receptor mutation influence clinical efficacy of EGFR-tyrosine kinase inhibitors in lung adenocarcinoma patients

Translational Cancer Research ◽

10.21037/tcr.2017.03.49 ◽

2017 ◽

Vol 6 (2) ◽

pp. 409-415

Author(s):

Lihong Ma ◽

Zhengbo Song ◽

Yong Song ◽

Yiping Zhang

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Lung Adenocarcinoma ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth

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Synthesis of Novel Benzoxazinone Compounds as Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors

Synthetic Communications ◽

10.1080/00397911.2011.573169 ◽

2012 ◽

Vol 42 (19) ◽

pp. 2937-2946 ◽

Cited By ~ 5

Author(s):

Shaopeng Chen ◽

Xuemin Li ◽

Shengbiao Wan ◽

Tao Jiang

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Egfr Tyrosine Kinase ◽

Egfr Tyrosine Kinase Inhibitors ◽

Epidermal Growth

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Management of oligometastasis and oligoprogression in patients with epidermal growth factor receptor mutation-positive NSCLC in the era of third-generation tyrosine kinase inhibitors

Clinical Lung Cancer ◽

10.1016/j.cllc.2021.03.004 ◽

2021 ◽

Author(s):

Jeong Uk Lim

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Third Generation ◽

Epidermal Growth

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Generations of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: A Battle against Drug Resistant Lung Cancer

Frontiers in Clinical Drug Research - Anti-Cancer Agents: Volume 5 - Frontiers in Clinical Drug Research - Anti-Cancer Agents ◽

10.2174/9789811405150119050008 ◽

2019 ◽

pp. 122-165

Author(s):

Kenneth K.W. To ◽

Wing-Sum Tong

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Receptor Tyrosine Kinase Inhibitors

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