Discovery of cannabinoid-1 receptor antagonists by virtual screening

2010 ◽  
Vol 20 (17) ◽  
pp. 5130-5132 ◽  
Author(s):  
Gil Nam Lee ◽  
Kwang Rok Kim ◽  
Sung-Hoon Ahn ◽  
Myung Ae Bae ◽  
Nam Sook Kang
Keyword(s):  
Virtual Screening ◽  
Receptor Antagonists ◽  
Cannabinoid 1 Receptor

Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2A Adenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors

2016 ◽  
Vol 22 (21) ◽  
pp. 3082-3096 ◽  
Author(s):  
Aliuska Morales Helguera ◽  
Yunierkis Perez-Castillo ◽  
M. Natália D.S. Cordeiro ◽  
Eduardo Tejera ◽  
César Paz-y-Miño ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Monoamine Oxidase ◽  
Adenosine Receptor ◽  
Monoamine Oxidase B ◽  
Receptor Antagonists ◽  
A2a Adenosine Receptor

ChemInform Abstract: Prospective Therapeutic Agents for Obesity: Molecular Modification Approaches of Centrally and Peripherally Acting Selective Cannabinoid 1 Receptor Antagonists

ChemInform ◽  
2014 ◽  
Vol 45 (29) ◽  
pp. no-no
Author(s):  
Mayank Kumar Sharma ◽  
Prashant R. Murumkar ◽  
Ashish M. Kanhed ◽  
Rajani Giridhar ◽  
Mange Ram Yadav
Keyword(s):  
Therapeutic Agents ◽  
Receptor Antagonists ◽  
Molecular Modification ◽  
Cannabinoid 1 Receptor

Prediction and Experimental Confirmation of Novel Peripheral Cannabinoid-1 Receptor Antagonists

2019 ◽  
Vol 59 (9) ◽  
pp. 3996-4006
Author(s):  
Shayma El-Atawneh ◽  
Shira Hirsch ◽  
Rivka Hadar ◽  
Joseph Tam ◽  
Amiram Goldblum
Keyword(s):  
Experimental Confirmation ◽  
Receptor Antagonists ◽  
Cannabinoid 1 Receptor

Identifying the structural features and diversifying the chemical domain of peripherally acting CB1 receptor antagonists using molecular modeling techniques

RSC Advances ◽  
2016 ◽  
Vol 6 (2) ◽  
pp. 1466-1483 ◽  
Author(s):  
Mayank Kumar Sharma ◽  
Prashant R. Murumkar ◽  
Guanglin Kuang ◽  
Yun Tang ◽  
Mange Ram Yadav
Keyword(s):  
Molecular Modeling ◽  
Virtual Screening ◽  
3D Qsar ◽  
Structural Features ◽  
Cb1 Receptor ◽  
Receptor Antagonists ◽  
Modeling Techniques ◽  
Qsar Models ◽  
Cb1 Receptor Antagonists

A four featured pharmacophore and predictive 3D-QSAR models were developed which were used for virtual screening of the Asinex database to get chemically diverse hits of peripherally active CB1 receptor antagonists.

First Pharmacophore Model of CCR3 Receptor Antagonists and its Homology Model-Assisted, Stepwise Virtual Screening

2011 ◽  
Vol 77 (5) ◽  
pp. 373-387 ◽  
Author(s):  
Vaibhav Jain ◽  
Parameswaran Saravanan ◽  
Akanksha Arvind ◽  
Chethampadi Gopi Mohan
Keyword(s):  
Virtual Screening ◽  
Pharmacophore Model ◽  
Homology Model ◽  
Receptor Antagonists

Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity

2007 ◽  
Vol 17 (10) ◽  
pp. 2706-2711 ◽  
Author(s):  
Roger A. Smith ◽  
Zahra Fathi ◽  
Furahi Achebe ◽  
Christiana Akuche ◽  
Su-Ellen Brown ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Cannabinoid 1 Receptor ◽  
Amide Derivatives ◽  
Treatment Of Obesity
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