Synthesis and antiglycation potentials of bergenin derivatives

Bergenin, which is isolated from Bergenia species, exhibits various pharmacological properties. In the search for new type of immunosuppressants, a series of bergenin derivatives were designed and synthesized, and their...

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Bergenin derivatives from Mallotus japonicus

Phytochemistry ◽

10.1016/s0031-9422(00)82451-6 ◽

1982 ◽

Vol 21 (5) ◽

pp. 1180-1182 ◽

Cited By ~ 38

Author(s):

Takashi Yoshida ◽

Kaoru Seno ◽

Yukiko Takama ◽

Takuo Okuda

Keyword(s):

Mallotus Japonicus ◽

Bergenin Derivatives

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Synthesis and cytotoxic activities of novel bergenin derivatives

Medicinal Chemistry Research ◽

10.1007/s00044-014-1050-9 ◽

2014 ◽

Vol 23 (11) ◽

pp. 4803-4813 ◽

Cited By ~ 1

Author(s):

Na-Na Liu ◽

Fu-Kai Bao ◽

Jing-Bo Chen ◽

Xiang-Hui Zeng ◽

Shui-Jing Chi ◽

...

Keyword(s):

Cytotoxic Activities ◽

Bergenin Derivatives

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Synthesis of new bergenin derivatives as potent inhibitors of inflammatory mediators NO and TNF-α

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.02.096 ◽

2012 ◽

Vol 22 (8) ◽

pp. 2744-2747 ◽

Cited By ~ 21

Author(s):

Muhammad Raza Shah ◽

Mohammad Arfan ◽

Hazrat Amin ◽

Zahid Hussain ◽

Muhammad Irfan Qadir ◽

...

Keyword(s):

Inflammatory Mediators ◽

Tnf Α ◽

Bergenin Derivatives

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SIRT1 Activation Enhancing 8,3′-Neolignans from the Twigs of Corylopsis coreana Uyeki

Plants ◽

10.3390/plants10081684 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1684

Author(s):

Hyun-Woo Kim ◽

Jin-Bum Jeon ◽

Mi Zhang ◽

Hyo-Moon Cho ◽

Byeol Ryu ◽

...

Keyword(s):

Phenolic Compounds ◽

Docking Study ◽

Stimulatory Activity ◽

Hydrolysable Tannins ◽

Binding Pockets ◽

Bergenin Derivatives

Three undescribed 8,3′-neolignans, corynol (1), 3-methoxy-corynol (2) and 3′-deoxy-corynol (3), together with two bergenin derivatives, three flavonoids, two hydrolysable tannins and six simple phenolic compounds, were isolated from the twigs of Corylopsis coreana Uyeki. The structures of the 8,3′-neolignans were elucidated by analyzing their NMR, HRESIMS and ECD spectra. All the isolated compounds were evaluated for their SIRT1 stimulatory activity, and 3′-deoxy-corynol (3) showed SIRT1 stimulation activity. Furthermore, a docking study of 3 was performed with three representative binding pockets of SIRT1.

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