Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors

2017 ◽  
Vol 27 (14) ◽  
pp. 3037-3042 ◽  
Author(s):  
Ling Tong ◽  
Seong Heon Kim ◽  
Kristin Rosner ◽  
Wensheng Yu ◽  
Bandarpalle B. Shankar ◽  
...  
Keyword(s):  
Tace Inhibitors

Tumor Necrosis Factor Alpha Converting Enzyme (TACE) as Possible Therapeutic Target in SARS-CoV-2 Induced Acute Respiratory Distress Syndrome (ARDS)

2020 ◽  
Author(s):  
Joao Batista Junior
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Inflammatory Responses ◽  
Converting Enzyme ◽  
Necrosis Factor Alpha ◽  
Tace Inhibitors ◽  
Factor Alpha ◽  
Activity State ◽  
Necrosis Factor

<div>This study reveals, for the first time, that rosiglitazone and pioglitazone, two thiazolidinedione drugs already approved as therapeutic agents to treat type II diabetes, were found to bind favorably to tumor necrosis factor alpha converting enzyme catalytic site with highlighted binding features.</div><div><br></div>This study suggests that rosiglitazone and pioglitazone, acting as TACE inhibitors agents might avoid or attenuate the hyperexcitability proteolytic activity state of TACE, represent a new potential therapeutic approach to treat SARS-CoV-2 infection-associated severe systemic inflammatory responses observed among severely or critically ill SARS-CoV-2 patients and, consequently, to diminish severe inflammatory‐induced lung injury, ARDS development and death rates.<br><br>

Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1′ groups

2002 ◽  
Vol 12 (8) ◽  
pp. 1195-1198 ◽  
Author(s):  
James M. Chen ◽  
Guixian Jin ◽  
Amy Sung ◽  
Jeremy I. Levin
Keyword(s):  
Tace Inhibitors

Design, synthesis and biological evaluation of γ-lactam hydroxamate based TACE inhibitors

MedChemComm ◽  
2011 ◽  
Vol 2 (10) ◽  
pp. 966 ◽  
Author(s):  
Anil Argade ◽  
Rajesh Bahekar ◽  
Jigar Desai ◽  
Pravin Thombare ◽  
Kiran Shah ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Tace Inhibitors ◽  
Synthesis And Biological Evaluation

Current perspective of TACE inhibitors: A review

2009 ◽  
Vol 17 (2) ◽  
pp. 444-459 ◽  
Author(s):  
Shirshendu DasGupta ◽  
Prashant R. Murumkar ◽  
Rajani Giridhar ◽  
Mange Ram Yadav
Keyword(s):  
Current Perspective ◽  
Tace Inhibitors

Identification of novel TACE inhibitors compatible with topical application

2017 ◽  
Vol 27 (8) ◽  
pp. 1848-1853 ◽  
Author(s):  
Gilles Ouvry ◽  
Yaël Berton ◽  
Yushma Bhurruth-Alcor ◽  
Laetitia Bonnary ◽  
Claire Bouix-Peter ◽  
...  
Keyword(s):  
Topical Application ◽  
Tace Inhibitors

Design and synthesis of 3,3-piperidine hydroxamate analogs as selective TACE inhibitors

2007 ◽  
Vol 17 (15) ◽  
pp. 4333-4337 ◽  
Author(s):  
Henry-Georges Lombart ◽  
Eric Feyfant ◽  
Diane Joseph-McCarthy ◽  
Adrian Huang ◽  
Frank Lovering ◽  
...  
Keyword(s):  
Design And Synthesis ◽  
Tace Inhibitors

The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors

2010 ◽  
Vol 20 (3) ◽  
pp. 1189-1193 ◽  
Author(s):  
Kristin E. Rosner ◽  
Zhuyan Guo ◽  
Peter Orth ◽  
Gerald W. Shipps ◽  
David B. Belanger ◽  
...  
Keyword(s):  
Converting Enzyme ◽  
Tnf Α ◽  
Tace Inhibitors
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