Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity

2019 ◽  
Vol 29 (23) ◽  
pp. 126748
Author(s):  
Tsuyoshi Arita ◽  
Masayoshi Asano ◽  
Kazufumi Kubota ◽  
Yuki Domon ◽  
Nobuo Machinaga ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Mu Opioid Receptor ◽  
Bicyclic Compound ◽  
Agonist Activity ◽  
Mu Opioid ◽  
Opioid Receptor Agonist

scholarly journals Orvinols with Mixed Kappa/Mu Opioid Receptor Agonist Activity

2013 ◽  
Vol 56 (8) ◽  
pp. 3207-3216 ◽  
Author(s):  
Benjamin M. Greedy ◽  
Faye Bradbury ◽  
Mark P. Thomas ◽  
Konstantinos Grivas ◽  
Gerta Cami-Kobeci ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Mu Opioid Receptor ◽  
Agonist Activity ◽  
Mu Opioid ◽  
Opioid Receptor Agonist

Discovery of DS34942424: An orally potent analgesic without mu opioid receptor agonist activity

2020 ◽  
Vol 28 (21) ◽  
pp. 115714
Author(s):  
Tsuyoshi Arita ◽  
Masayoshi Asano ◽  
Kazufumi Kubota ◽  
Yuki Domon ◽  
Nobuo Machinaga ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Mu Opioid Receptor ◽  
Agonist Activity ◽  
Mu Opioid ◽  
Opioid Receptor Agonist

scholarly journals A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

2018 ◽  
Vol 10 (456) ◽  
pp. eaar3483 ◽  
Author(s):  
Huiping Ding ◽  
Norikazu Kiguchi ◽  
Dennis Yasuda ◽  
Pankaj R. Daga ◽  
Willma E. Polgar ◽  
...  
Keyword(s):  
Side Effects ◽  
Opioid Receptor ◽  
Receptor Agonist ◽  
Nonhuman Primates ◽  
Mu Opioid Receptor ◽  
Mu Opioid ◽  
Opioid Receptor Agonist

scholarly journals Peripherally acting mu-opioid receptor agonist attenuates neuropathic pain in rats after L5 spinal nerve injury

Pain ◽  
2008 ◽  
Vol 138 (2) ◽  
pp. 318-329 ◽  
Author(s):  
Yun Guan ◽  
Lisa M. Johanek ◽  
Timothy V. Hartke ◽  
Beom Shim ◽  
Yuan-Xiang Tao ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Opioid Receptor ◽  
Receptor Agonist ◽  
Mu Opioid Receptor ◽  
Spinal Nerve ◽  
Mu Opioid ◽  
Opioid Receptor Agonist

scholarly journals Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice

2020 ◽  
Vol 132 ◽  
pp. 110794
Author(s):  
Fanny Joubert ◽  
Adrian Guerrero-Moreno ◽  
Darine Fakih ◽  
Elodie Reboussin ◽  
Claire Gaveriaux-Ruff ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Topical Treatment ◽  
Receptor Agonist ◽  
Mu Opioid Receptor ◽  
Mu Opioid ◽  
Opioid Receptor Agonist ◽  
Corneal Nerve
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