Objective: Using an interpersonal theory of suicide framework, we investigated the relationships between perceived burdensomeness, thwarted belongingness, weight stigmatization, emotion dysregulation, eating disorder symptoms, and suicide risk. Three hypotheses were investigated. First, we predicted a positive linear relationship between stigmatization and risk. Second, an indirect effect of stigmatization on risk via thwarted belongingness and perceived burdensomeness was posited. Third, we hypothesized that weight stigmatization would indirectly affect suicide risk via emotion dysregulation as conditional upon disordered eating. Method: Undergraduates (N = 156) completed surveys online. Linear regressions, indirect effect analyses, and conditional process modeling were conducted to test our hypotheses. Results: Weight stigmatization was associated with suicide risk, where higher levels of stigmatization were associated with higher levels of suicide risk. Weight stigmatization indirectly affected suicide risk via perceived burdensomeness but not thwarted belongingness. Higher stigmatization was associated with higher levels of perceived burdensomeness, which was associated with higher risk. An indirect effect of weight stigmatization on suicide risk through emotional dysregulation emerged. Higher weight stigmatization was associated with higher emotional dysregulation, which was associated with higher suicide risk. Conclusions: Our findings may have clinical and public health implications for suicide prevention efforts targeting weight stigma-related risk factors.