scholarly journals Therapeutic impact of low amplitude high frequency whole body vibrations on the osteogenesis imperfecta mouse bone

Bone ◽  
2013 ◽  
Vol 53 (2) ◽  
pp. 507-514 ◽  
Author(s):  
Maximilien Vanleene ◽  
Sandra J. Shefelbine
PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10388
Author(s):  
Miloš Kalc ◽  
Ramona Ritzmann ◽  
Vojko Strojnik

Background Whole body vibrations have been used as an exercise modality or as a tool to study neuromuscular integration. There is increasing evidence that longer WBV exposures (up to 10 minutes) induce an acute impairment in neuromuscular function. However, the magnitude and origin of WBV induced fatigue is poorly understood. Purpose The study aimed to investigate the magnitude and origin of neuromuscular fatigue induced by half-squat long-exposure whole-body vibration intervention (WBV) with sets of different duration and compare it to non-vibration (SHAM) conditions. Methods Ten young, recreationally trained adults participated in six fatiguing trials, each consisting of maintaining a squatting position for several sets of the duration of 30, 60 or 180 seconds. The static squatting was superimposed with vibrations (WBV30, WBV60, WBV180) or without vibrations (SHAM30, SHAM60, SHAM180) for a total exercise exposure of 9-minutes in each trial. Maximum voluntary contraction (MVC), level of voluntary activation (%VA), low- (T20) and high-frequency (T100) doublets, low-to-high-frequency fatigue ratio (T20/100) and single twitch peak torque (TWPT) were assessed before, immediately after, then 15 and 30 minutes after each fatiguing protocol. Result Inferential statistics using RM ANOVA and post hoc tests revealed statistically significant declines from baseline values in MVC, T20, T100, T20/100 and TWPT in all trials, but not in %VA. No significant differences were found between WBV and SHAM conditions. Conclusion Our findings suggest that the origin of fatigue induced by WBV is not significantly different compared to control conditions without vibrations. The lack of significant differences in %VA and the significant decline in other assessed parameters suggest that fatiguing protocols used in this study induced peripheral fatigue of a similar magnitude in all trials.


2005 ◽  
Vol 98 (6) ◽  
pp. 2376-2380 ◽  
Author(s):  
Walter L. Murfee ◽  
Laura A. Hammett ◽  
Caroline Evans ◽  
Liqin Xie ◽  
Maria Squire ◽  
...  

Extremely low-magnitude (0.3 g), high-frequency (30–90 Hz), whole body vibrations can stimulate bone formation and are hypothesized to provide a surrogate for the oscillations of muscle during contraction. Little is known, however, about the potential of these mechanical signals to stimulate adaptive responses in other tissues. The objective of this study was to determine whether low-level mechanical signals produce structural adaptations in the vasculature of skeletal muscle. Eight-week-old male BALB/cByJ (BALB) mice were divided into two experimental groups: mice subjected to low-level, whole body vibrations (45 Hz, 0.3 g) superimposed on normal cage activities for 15 min/day ( n = 6), and age-matched controls ( n = 7). After the 6-wk experimental protocol, sections from end and mid regions of the soleus muscles were stained with lectin from Bandeiraea Simplicifolia, an endothelial cell marker, and smooth muscle (SM) α-actin, a perivascular cell marker. Six weeks of this low-level vibration caused a 29% decrease in the number of lectin-positive vessels per muscle fiber in the end region of the soleus muscle, indicating a significant reduction in the number of capillaries per muscle fibers. Similarly, these vibrations caused a 36% reduction in SM α-actin-positive vessels per muscle fiber, indicating a reduction in the number of arterioles and venules. The decreases in lectin- and SM α-actin-positive vessels per muscle fiber ratios were not significant in the mid muscle sections. These results demonstrate the sensitivity of the vasculature in mouse skeletal muscle to whole body, low-level mechanical signals.


Bone ◽  
2012 ◽  
Vol 50 ◽  
pp. S172
Author(s):  
M. Vanleene⁎ ◽  
S.J. Shefelbine

2005 ◽  
Vol 44 (01) ◽  
pp. 8-14 ◽  
Author(s):  
B. Dietl ◽  
J. Marienhagen

Summary Aims: An explorative analysis of the diagnostic as well as therapeutic impact of 18F-FDG whole body PET on patients with various tumours in the setting of an university hospital radiation therapy was performed. Patients and methods: 222 FDG PET investigations (148 initial stagings, 74 restagings) in 176 patients with diverse tumour entities (37 lung carcinoma, 15 gastrointestinal tumours, 38 head and neck cancer, 30 lymphoma, 37 breast cancer, 19 sarcoma and 16 other carcinomas) were done. All PET scans were evaluated in an interdisciplinary approach and consecutively confirmed by other imaging modalities or biopsy. Unconfirmed PET findings were ignored. Proportions of verified PET findings, additional diagnostic information (diagnostic impact) and changes of the therapeutic concept intended and documented before PET with special emphasis on radiooncological decisions (therapeutic impact) were analysed. Results: 195/222 (88%) FDG-PET findings were verified, 104/222 (47%) FDG-PET scans yielded additional diagnostic information (38 distant, 30 additional metastasis, 11 local recurrencies, 10 primary tumours and 15 residual tumours after chemoptherapy). The results of 75/222 (34%) scans induced changes in cancer therapy and those of 58/222 (26%) scans induced modifications of radiotherapeutic treatment plan (esp. target volumes). Conclusion: 18F-FDG whole body PET is a valuable diagnostic tool for therapy planning in radiooncology with a high impact on therapeutic decisions in initial staging as well as in restaging. Especially in a curative setting it should be used for definition of target volumes.


2006 ◽  
Vol 25 (3) ◽  
pp. 175-184 ◽  
Author(s):  
James P. Dickey ◽  
Michele L. Oliver ◽  
Paul-Emile Boileau ◽  
Tammy R. Eger ◽  
Lana M. Trick ◽  
...  

2009 ◽  
Author(s):  
James P. Ryle ◽  
Mohammed Al-Kalbani ◽  
Unnikrishnan Gopinathan ◽  
Gerard Boyle ◽  
Davis Coakley ◽  
...  

2021 ◽  
Vol 263 (2) ◽  
pp. 4913-4918
Author(s):  
Anna Schwendicke ◽  
M. Ercan Altinsoy

Humans perceive whole-body vibration in many daily life situations. Often they are exposed to whole-body vibration in combination with acoustic events. Sound and vibration usually stems from the same source, for example concerts or travelling in vehicles, such as automobile, aircrafts, or ships. While we can describe acoustic stimuli using psychoacoustic descriptors such as loudness or timbre, the description human perception of whole body vibration frequently has been reduced to comfort or quality in the past. Unlike loudness or timbre, comfort and quality are dependent on the overall context. Especially in vehicles expectations might differ lot between different vehicle classes. Previous studies have evaluated a large range of suitable descriptors for whole-body vibrations that are independent of context. They suggest that certain descriptors are driven to a large extend by the frequency content of the vibration. This study systematically investigates the influence of frequency content on the perception of whole-body vibration varying frequency content and intensity of the vibrations. The results verify the frequency dependence of specific descriptors and identify the respective frequency ranges.


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