scholarly journals Disturbance of osteonal bone remodeling and high tensile stresses on the lateral cortex in atypical femoral fracture after long-term treatment with Risedronate and Alfacalcidol for osteoporosis

Bone Reports ◽  
2021 ◽  
pp. 101091
Author(s):  
Fumitaka Hirano ◽  
Kayoko Furukawa Okuma ◽  
Yukichi Zenke ◽  
Kunitaka Menuki ◽  
Hideo Ohnishi ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Femoral Fracture ◽  
Term Treatment ◽  
Atypical Femoral Fracture ◽  
Lateral Cortex ◽  
Tensile Stresses ◽  
Long Term Treatment ◽  
Osteonal Bone

scholarly journals Focal Cortical Thickening along the Lateral Aspect of the Proximal Femoral Shaft: A Warning Radiographic Sign for Subsequent Complete Atypical Femoral Fracture in Patients on Bisphosphonates

2017 ◽  
Vol 03 (01) ◽  
pp. 058-060
Author(s):  
Sachin Agrawal ◽  
Amelia Santosa
Keyword(s):  
Femoral Fracture ◽  
Major Trauma ◽  
Groin Pain ◽  
Radiographic Finding ◽  
Femoral Shaft ◽  
Term Treatment ◽  
Atypical Femoral Fracture ◽  
Lateral Aspect ◽  
Long Term Treatment

AbstractAtypical femoral fracture is a known complication of patients receiving long-term bisphosphonates for osteoporosis. Recognizing early radiographic features is important to provide timely care and management before the development of a more debilitating complete fracture with its associated morbidity and mortality. We report a case of a 72-year-old lady on long-term treatment with alendronate, who presented initially with groin pain and subsequently with a femoral fracture, without any major trauma. The initial radiographic finding of focal thickening along the lateral cortex of the proximal femur was missed.

scholarly journals Fraturas Atípicas do Fémur Associadas a Terapêutica Prolongada com Bisfosfonatos

2013 ◽  
Vol 26 (6) ◽  
pp. 746
Author(s):  
Francisco Flores Santos ◽  
José Pinheiro da Silva ◽  
Paulo Felicíssimo
Keyword(s):  
Femoral Fracture ◽  
Scientific Evidence ◽  
Femoral Fractures ◽  
Osteoporotic Fractures ◽  
Femoral Shaft ◽  
Term Treatment ◽  
Atypical Femoral Fractures ◽  
Long Term Treatment

Introduction: Long-term treatment with bisphosphonates has been associated to atypical femoral fractures whose features are now clearly defined.Clinical Cases: We present two cases of female patients under bisphosphonate treatment for over 10 years who were admitted to our institution for subtrochanteric and femoral shaft fractures after low-energy trauma. They presented, respectively, a transverse and a short oblique femoral fracture, with thickening of the lateral cortex. They underwent surgical treatment obtaining good functional and imaging result.Discussion: These cases fulfill the established criteria for atypical femoral fracture, thereby illustrating a serious adverse event of long-term treatment with bisphosphonates. Such relationship has still not been clearly established by scientific evidence. However, its effectiveness in preventing osteoporotic fractures is well proven.Conclusion: The atypical femoral fractures are possibly a serious adverse effect of the long-term treatment with bisphosphonates. Scientific evidence still supports its use, however, the physician must be aware of these events and closely follow-up these patients.

Hypnotherapy is effective in the long-term treatment of functional dyspepsia

2001 ◽  
Vol 120 (5) ◽  
pp. A115-A115 ◽  
Author(s):  
E CALVERT ◽  
L HOUGHTON ◽  
P COOPER ◽  
P WHORWELL
Keyword(s):  
Functional Dyspepsia ◽  
Term Treatment ◽  
Long Term Treatment

1608: Long-Term Treatment with High Doses of Sildenafil Does Not Up-Regulate the Levels of Phosphodiesterase 5 (Pde5) in the Rat Penis

2004 ◽  
Vol 171 (4S) ◽  
pp. 424-424 ◽  
Author(s):  
Monica G. Ferrini ◽  
Eliane G. Valente ◽  
Jacob Rajfer ◽  
Nestor F. Gonzalez-Cadavid
Keyword(s):  
Term Treatment ◽  
Long Term Treatment ◽  
High Doses ◽  
Phosphodiesterase 5

Long-Term Treatment Outcomes for Heroin Dependence: The 11-Year Follow-Up of the ATOS Study

2013 ◽  
Author(s):  
Christina Marel ◽  
Maree Teesson ◽  
Shane Darke ◽  
Katherine Mills ◽  
Joanne Ross ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Term Treatment ◽  
Heroin Dependence ◽  
Long Term Treatment
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