scholarly journals Single Molecule Analysis of Human Telomerase RNA Pseudoknot Folding and Dynamics

2012 ◽  
Vol 102 (3) ◽  
pp. 644a
Author(s):  
Martin Hengesbach ◽  
Michael D. Stone
Keyword(s):  
Single Molecule ◽  
Telomerase Rna ◽  
Human Telomerase ◽  
Rna Pseudoknot ◽  
Single Molecule Analysis

scholarly journals Single-Molecule FRET Reveals the Folding Dynamics of the Human Telomerase RNA Pseudoknot Domain

2012 ◽  
Vol 51 (24) ◽  
pp. 5876-5879 ◽  
Author(s):  
Martin Hengesbach ◽  
Nak-Kyoon Kim ◽  
Juli Feigon ◽  
Michael D. Stone
Keyword(s):  
Single Molecule ◽  
Telomerase Rna ◽  
Single Molecule Fret ◽  
Folding Dynamics ◽  
Human Telomerase ◽  
Rna Pseudoknot

Single-Molecule FRET Reveals the Folding Dynamics of the Human Telomerase RNA Pseudoknot Domain

2012 ◽  
Vol 124 (24) ◽  
pp. 5978-5981 ◽  
Author(s):  
Martin Hengesbach ◽  
Nak-Kyoon Kim ◽  
Juli Feigon ◽  
Michael D. Stone
Keyword(s):  
Single Molecule ◽  
Telomerase Rna ◽  
Single Molecule Fret ◽  
Folding Dynamics ◽  
Human Telomerase ◽  
Rna Pseudoknot

scholarly journals Erratum: Single-molecule analysis of human telomerase monomer

2008 ◽  
Vol 4 (6) ◽  
pp. 379-379
Author(s):  
David Alves ◽  
Haitao Li ◽  
Rosalind Codrington ◽  
Angel Orte ◽  
Xiaojun Ren ◽  
...  
Keyword(s):  
Single Molecule ◽  
Human Telomerase ◽  
Single Molecule Analysis

scholarly journals Multiplexed single-molecule analysis of human telomerase synthesizing DNA

2021 ◽  
Author(s):  
Jendrik Hentschel ◽  
Junhong Choi ◽  
Clive R. Bagshaw ◽  
Christopher P. Lapointe ◽  
Jinfan Wang ◽  
...  
Keyword(s):  
Single Molecule ◽  
Direct Detection ◽  
Telomere Maintenance ◽  
Proliferating Cells ◽  
Single Nucleotide ◽  
Human Telomerase ◽  
Nucleotide Resolution ◽  
Nucleic Acid Polymerase ◽  
Single Molecule Analysis ◽  
Single Nucleotide Resolution

Genomic stability in proliferating cells critically depends on telomere maintenance by telomerase reverse transcriptase. Here we developed a real-time single-molecule RNA sequencing approach that visualizes telomerase catalysis and structural dynamics at single-nucleotide resolution using FRET and zero-mode waveguides. The method permits direct detection of dynamic steps and structural states throughout the telomerase catalytic cycle and can be generalized to other nucleic acid polymerase systems.

Single-molecule analysis of human telomerase monomer

2008 ◽  
Vol 4 (5) ◽  
pp. 287-289 ◽  
Author(s):  
David Alves ◽  
Haitao Li ◽  
Rosalind Codrington ◽  
Angel Orte ◽  
Xiaojun Ren ◽  
...  
Keyword(s):  
Single Molecule ◽  
Human Telomerase ◽  
Single Molecule Analysis
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