scholarly journals AFM Reveals Age-Dependent Micromechanical Degradation of Cardiopulmonary Tissues in a Mouse Model of Marfan Syndrome

2015 ◽  
Vol 108 (2) ◽  
pp. 295a-296a
Author(s):  
Jia-Jye Lee ◽  
Satish Rao ◽  
Josephine Galatioto ◽  
Francesco Ramirez ◽  
Kevin D. Costa
Keyword(s):  
Mouse Model ◽  
Marfan Syndrome ◽  
Age Dependent

scholarly journals Hyperkyphosis is not dependent on bone mass and quality in the mouse model of Marfan syndrome

Bone ◽  
2021 ◽  
pp. 116073
Author(s):  
Rodrigo Barbosa de Souza ◽  
Elisa Ito Kawahara ◽  
Luis Ernesto Farinha-Arcieri ◽  
Isabela Gerdes Gyuricza ◽  
Bianca Neofiti Papi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Bone Mass ◽  
Marfan Syndrome

Deletion of murine tau gene increases tau aggregation in a human mutant tau transgenic mouse model

2010 ◽  
Vol 38 (4) ◽  
pp. 1001-1005 ◽  
Author(s):  
Kunie Ando ◽  
Karelle Leroy ◽  
Céline Heraud ◽  
Anna Kabova ◽  
Zehra Yilmaz ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Double Mutant ◽  
Transgenic Mouse Model ◽  
Tau Proteins ◽  
Dependent Manner ◽  
Age Dependent ◽  
Ad Alzheimer’S Disease ◽  
Tau Aggregation ◽  
The Brain

We have reported previously a tau transgenic mouse model (Tg30tau) overexpressing human 4R1N double-mutant tau (P301S and G272V) and that develops AD (Alzheimer's disease)-like NFTs (neurofibrillary tangles) in an age-dependent manner. Since murine tau might interfere with the toxic effects of human mutant tau, we set out to analyse the phenotype of our Tg30tau model in the absence of endogenous murine tau with the aim to reproduce more faithfully a model of human tauopathy. By crossing the Tg30tau line with TauKO (tau-knockout) mice, we have obtained a new mouse line called Tg30×TauKO that expresses only exogenous human double-mutant 4R1N tau. Whereas Tg30×TauKO mice express fewer tau proteins compared with Tg30tau, they exhibit augmented sarkosyl-insoluble tau in the brain and an increased number of Gallyas-positive NFTs in the hippocampus. Taken together, exclusion of murine tau causes accelerated tau aggregation during aging of this mutant tau transgenic model.

scholarly journals Defective Age-Dependent Metaplasticity in a Mouse Model of Alzheimer's Disease

2015 ◽  
Vol 35 (32) ◽  
pp. 11346-11357 ◽  
Author(s):  
A. Megill ◽  
T. Tran ◽  
K. Eldred ◽  
N. J. Lee ◽  
P. C. Wong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Age Dependent

scholarly journals Age‑dependent concomitant changes in synaptic function and GABAergic pathway in the APP/PS1 mouse model

2016 ◽  
Vol 76 (4) ◽  
pp. 282-293 ◽  
Author(s):  
Tutu Oyelami ◽  
An De Bondt ◽  
Ilse Van den Wyngaert ◽  
Kirsten Van Hoorde ◽  
Luc Hoskens ◽  
...  
Keyword(s):  
Mouse Model ◽  
Synaptic Function ◽  
Age Dependent

scholarly journals Mechanics of Carotid Arteries in a Mouse Model of Marfan Syndrome

2009 ◽  
Vol 37 (6) ◽  
pp. 1093-1104 ◽  
Author(s):  
J. F. Eberth ◽  
A. I. Taucer ◽  
E. Wilson ◽  
J. D. Humphrey
Keyword(s):  
Mouse Model ◽  
Marfan Syndrome ◽  
Carotid Arteries

scholarly journals Cardiac Remodeling in the Mouse Model of Marfan Syndrome Develops Independently from Aortic and Valvular Abnormalities

2015 ◽  
Vol 108 (2) ◽  
pp. 595a
Author(s):  
Natalia Petrashevskaya ◽  
Hyun-Jin Tae ◽  
Shanon Marshall ◽  
Melissa Krawczyk ◽  
Mark Talan
Keyword(s):  
Mouse Model ◽  
Marfan Syndrome ◽  
Cardiac Remodeling
Sign in / Sign up

Export Citation Format

Share Document