scholarly journals Structure and Topology of the SERCA Regulator DWORF in Lipid Bilayers by Oriented Sample Solid-State NMR

2020 ◽  
Vol 118 (3) ◽  
pp. 209a
Author(s):  
Venkateswara Reddy Uddigiri ◽  
Daniel Weber ◽  
Songlin Wang ◽  
Erik K. Larsen ◽  
Seth L. Robia ◽  
...  
Keyword(s):  
Solid State ◽  
Lipid Bilayers ◽  
Solid State Nmr ◽  
Oriented Sample ◽  
And Topology

Structural Dynamics and Topology of Phospholamban in Oriented Lipid Bilayers Using Multidimensional Solid-State NMR†

Biochemistry ◽  
2006 ◽  
Vol 45 (46) ◽  
pp. 13827-13834 ◽  
Author(s):  
N. J. Traaseth ◽  
J. J. Buffy ◽  
J. Zamoon ◽  
G. Veglia
Keyword(s):  
Solid State ◽  
Lipid Bilayers ◽  
Structural Dynamics ◽  
Solid State Nmr ◽  
And Topology

scholarly journals A Theoretical Assessment of the Structure Determination of Multi-Span Membrane Proteins by Oriented Sample Solid-State NMR Spectroscopy

2020 ◽  
Vol 73 (3) ◽  
pp. 246 ◽  
Author(s):  
Daniel K. Weber ◽  
Gianluigi Veglia
Keyword(s):  
Solid State ◽  
Membrane Proteins ◽  
Lipid Bilayers ◽  
Solid State Nmr ◽  
Direct Determination ◽  
Oriented Sample ◽  
Dynamics Simulations ◽  
G Protein Coupled ◽  
Theoretical Assessment

Oriented sample solid-state NMR (OS-ssNMR) spectroscopy allows the direct determination of the structure and topology of membrane proteins reconstituted into aligned lipid bilayers. Although OS-ssNMR theoretically has no upper size limit, its application to multi-span membrane proteins has not been established because most studies have been restricted to single- or dual-span proteins and peptides. Here, we present a critical assessment of the application of this method to multi-span membrane proteins. We used molecular dynamics simulations to back-calculate [15N-1H] separated local field (SLF) spectra from a G protein-coupled receptor (GPCR) and show that fully resolved spectra can be obtained theoretically for a multi-span membrane protein with currently achievable resonance linewidths.

scholarly journals Solid-State NMR/Dynamic Nuclear Polarization of Polypeptides in Planar Supported Lipid Bilayers

2015 ◽  
Vol 119 (46) ◽  
pp. 14574-14583 ◽  
Author(s):  
Evgeniy S. Salnikov ◽  
Hiba Sarrouj ◽  
Christian Reiter ◽  
Christopher Aisenbrey ◽  
Armin Purea ◽  
...  
Keyword(s):  
Solid State ◽  
Lipid Bilayers ◽  
Dynamic Nuclear Polarization ◽  
Solid State Nmr ◽  
Nuclear Polarization ◽  
Supported Lipid Bilayers

Solid State NMR Investigation of the Interaction between Biomimetic Lipid Bilayers and de novo Designed Fusogenic Peptides

ChemBioChem ◽  
2007 ◽  
Vol 8 (5) ◽  
pp. 493-496 ◽  
Author(s):  
Prashant Agrawal ◽  
Suzanne Kiihne ◽  
Johan Hollander ◽  
Frans Hulsbergen ◽  
Mathias Hofmann ◽  
...  
Keyword(s):  
Solid State ◽  
Lipid Bilayers ◽  
Solid State Nmr ◽  
De Novo ◽  
Fusogenic Peptides
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