scholarly journals Kinesin ATP Hydrolysis Requires Proton Tunneling within the Zundel Cation and a Second Proton Transfer

2021 ◽  
Vol 120 (3) ◽  
pp. 162a-163a
Author(s):  
Micquel Downs ◽  
Jessica M. Richard ◽  
Courtney Bryan Parke ◽  
Minmin Luo ◽  
Elizabeth Kim ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Atp Hydrolysis ◽  
Proton Tunneling

Proton transfer processes in selenourea: UV-induced selenone→selenol photoreaction and ground state selenol→selenone proton tunneling

2004 ◽  
Vol 298 (1-3) ◽  
pp. 223-232 ◽  
Author(s):  
Hanna Rostkowska ◽  
Leszek Lapinski ◽  
Artem Khvorostov ◽  
Maciej J. Nowak
Keyword(s):  
Proton Transfer ◽  
Ground State ◽  
Proton Tunneling ◽  
Transfer Processes

Concerted electron and proton transfer: Transition from nonadiabatic to adiabatic proton tunneling

2000 ◽  
Vol 113 (23) ◽  
pp. 10438-10450 ◽  
Author(s):  
Yuri Georgievskii ◽  
Alexei A. Stuchebrukhov
Keyword(s):  
Proton Transfer ◽  
Proton Tunneling

An ab initio study of the structure and intramolecular proton transfer in tropolone

1991 ◽  
Vol 69 (2) ◽  
pp. 201-204 ◽  
Author(s):  
Miguel A. Ríos ◽  
Jesús Rodríguez
Keyword(s):  
Proton Transfer ◽  
Ab Initio ◽  
Ground State ◽  
Vibrational State ◽  
Intramolecular Proton Transfer ◽  
Ab Initio Study ◽  
Proton Tunneling ◽  
Full Optimization ◽  
Minimum Potential ◽  
Intramolecular Hydrogen

An ab initio study of tropolone was carried out at the 3-21G level, with full optimization of the geometry, and the intramolecular proton transfer in the ground state was analysed. The two equivalent Cs structures can be converted to each other via a C2v symmetry transition state with a double minimum potential. The splitting of the ground vibrational state generated by proton tunneling was determined by procedures of variable complexity and found to be in the range Δ = 0.1–0.15 cm−1, i.e., clearly smaller than experimental predictions. Key words: tropolone, intramolecular hydrogen bond, proton transfer, ab initio calculations, molecular structure.

scholarly journals Molecular dynamics simulation of proton-transfer coupled rotations in ATP synthase FO motor

2019 ◽  
Author(s):  
Shintaroh Kubo ◽  
Toru Niina ◽  
Shoji Takada
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulation ◽  
Proton Transfer ◽  
Atp Synthase ◽  
Atp Hydrolysis ◽  
Atp Synthesis ◽  
Simulation Method ◽  
Proton Pumping ◽  
Dynamics Simulation ◽  
Transduction Efficiency

AbstractThe FO motor in FOF1 ATP synthase rotates its rotor driven by the proton motive force. While earlier studies elucidated basic mechanisms therein, recent advances in high-resolution cryo-electron microscopy enabled to investigate proton-transfer coupled FO rotary dynamics at structural details. Here, developing a hybrid Monte Carlo/molecular dynamics simulation method, we studied reversible dynamics of a yeast mitochondrial FO. We obtained the 36°-stepwise rotations of FO per one proton transfer in the ATP synthesis mode and the proton pumping in the ATP hydrolysis mode. In both modes, the most prominent path alternatively sampled states with two and three deprotonated glutamates in c-ring, by which the c-ring rotates one step. The free energy transduction efficiency in the model FO motor reaches ~ 90% in optimal conditions. Moreover, mutations in key glutamate and a highly conserved arginine increased proton leakage and markedly decreased the coupling, in harmony with previous experiments.

scholarly journals Quantum proton tunneling in multi-electron/-proton transfer electrode processes

2020 ◽  
Vol 221 ◽  
pp. 428-448 ◽  
Author(s):  
Ken Sakaushi
Keyword(s):  
Proton Transfer ◽  
Proton Tunneling ◽  
Electrode Processes ◽  
Electron Proton Transfer

Quantum proton tunneling in multi-electron/-proton transfer electrode processes were investigated in order to understand their possible microscopic mechanisms.

scholarly journals Proton Tunneling Accelerates ATP Hydrolysis in Eg5 Kinesin

2012 ◽  
Vol 102 (3) ◽  
pp. 367a
Author(s):  
Courtney Parke ◽  
Elizabeth D. Kim ◽  
Jessica Richard ◽  
David Worthylake ◽  
Sunyoung Kim
Keyword(s):  
Atp Hydrolysis ◽  
Proton Tunneling

scholarly journals Proton Tunneling Accelerates ATP Hydrolysis in Kinesin‐5 Proteins

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Sunyoung Kim ◽  
Jessica Richard ◽  
Courtney Parke ◽  
David Worthylake ◽  
Edward Wojcik
Keyword(s):  
Atp Hydrolysis ◽  
Proton Tunneling
Sign in / Sign up

Export Citation Format

Share Document