Effect of upregulated renin–angiotensin system on per2 and bmal1 gene expression in brain structures involved in blood pressure control in TGR(mREN-2)27 rats

2007 ◽  
Vol 1180 ◽  
pp. 29-38 ◽  
Author(s):  
Jana Monošíková ◽  
Iveta Herichová ◽  
Boris Mravec ◽  
Alexander Kiss ◽  
Michal Zeman
Keyword(s):  
Gene Expression ◽  
Blood Pressure ◽  
Blood Pressure Control ◽  
Renin Angiotensin System ◽  
Brain Structures ◽  
Pressure Control ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Harry Goldblatt and the discovery of renin

2005 ◽  
Vol 201 (9) ◽  
pp. 1351-1351 ◽  
Author(s):  
Heather L. Van Epps
Keyword(s):  
Blood Pressure ◽  
Animal Model ◽  
Blood Pressure Control ◽  
Enzyme Inhibitors ◽  
Renin Angiotensin System ◽  
Pressure Control ◽  
Chronic Hypertension ◽  
Angiotensin System ◽  
Renin Angiotensin

In 1934, pathologist Harry Goldblatt established the first animal model of hypertension. This model provided researchers with the tools to delineate the renin-angiotensin system of blood pressure control and, eventually, to design enzyme inhibitors for the treatment of chronic hypertension.

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