Valsartan chronotherapy reverts the non-dipper pattern and improves blood pressure control through mediation of circadian rhythms of the renin-angiotensin system in spontaneous hypertension rats

2019 ◽  
Vol 36 (8) ◽  
pp. 1058-1071 ◽  
Author(s):  
Kui Yang ◽  
Yaqin Wang ◽  
Yanyun Ding ◽  
Haiju Cui ◽  
Deixi Zhou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Circadian Rhythms ◽  
Blood Pressure Control ◽  
Renin Angiotensin System ◽  
Pressure Control ◽  
Spontaneous Hypertension ◽  
Angiotensin System ◽  
Renin Angiotensin

scholarly journals Harry Goldblatt and the discovery of renin

2005 ◽  
Vol 201 (9) ◽  
pp. 1351-1351 ◽  
Author(s):  
Heather L. Van Epps
Keyword(s):  
Blood Pressure ◽  
Animal Model ◽  
Blood Pressure Control ◽  
Enzyme Inhibitors ◽  
Renin Angiotensin System ◽  
Pressure Control ◽  
Chronic Hypertension ◽  
Angiotensin System ◽  
Renin Angiotensin

In 1934, pathologist Harry Goldblatt established the first animal model of hypertension. This model provided researchers with the tools to delineate the renin-angiotensin system of blood pressure control and, eventually, to design enzyme inhibitors for the treatment of chronic hypertension.

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