BackgroundThis study compared the best available treatment for bulimia nervosa,
cognitive–behavioural therapy (CBT) augmented by fluoxetine if indicated,
with a stepped-care treatment approach in order to enhance treatment
effectiveness.AimsTo establish the relative effectiveness of these two approaches.MethodThis was a randomised trial conducted at four clinical centres
(Clinicaltrials.gov registration number: NCT00733525). A total of 293
participants with bulimia nervosa were randomised to one of two treatment
conditions: manual-based CBT delivered in an individual therapy format
involving 20 sessions over 18 weeks and participants who were predicted
to be non-responders after 6 sessions of CBT had fluoxetine added to
treatment; or a stepped-care approach that began with supervised
self-help, with the addition of fluoxetine in participants who were
predicted to be non-responders after six sessions, followed by CBT for
those who failed to achieve abstinence with self-help and medication
management.ResultsBoth in the intent-to-treat and completer samples, there were no
differences between the two treatment conditions in inducing recovery (no
binge eating or purging behaviours for 28 days) or remission (no longer
meeting DSM–IV criteria). At the end of 1-year follow-up, the
stepped-care condition was significantly superior to CBT.ConclusionsTherapist-assisted self-help was an effective first-level treatment in
the stepped-care sequence, and the full sequence was more effective than
CBT suggesting that treatment is enhanced with a more individualised
approach.