1,2,3,4,6-Penta-O-galloyl-beta--glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor

2004 ◽  
Vol 208 (1) ◽  
pp. 89-94 ◽  
Author(s):  
S LEE ◽  
H LEE ◽  
S JI ◽  
S LEE ◽  
W MAR ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Growth ◽  
Tube Formation ◽  
Vegf Receptor ◽  
Endothelial Cell Growth

scholarly journals Vascular Endothelial Cell Growth Factor A Acts via Platelet-Derived Growth Factor Receptor α To Promote Viability of Cells Enduring Hypoxia

2016 ◽  
Vol 36 (18) ◽  
pp. 2314-2327 ◽  
Author(s):  
Steven Pennock ◽  
Leo A. Kim ◽  
Andrius Kazlauskas
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Cell Growth ◽  
Vascular Endothelial Cell ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Vegf Receptor ◽  
Vascular Endothelial ◽  
Endothelial Cell Growth Factor ◽  
Endothelial Cell Growth

Vascular endothelial cell growth factor A (VEGF) is a biologically and therapeutically important growth factor because it promotes angiogenesis in response to hypoxia, which underlies a wide variety of both physiological and pathological settings. We report here that both VEGF receptor 2 (VEGFR2)-positive and -negative cells depended on VEGF to endure hypoxia. VEGF enhanced the viability of platelet-derived growth factor receptor α (PDGFRα)-positive and VEGFR2-negative cells by enabling indirect activation of PDGFRα, thereby reducing the level of p53. We conclude that the breadth of VEGF's influence extends beyond VEGFR-positive cells and propose a plausible mechanistic explanation of this phenomenon.

NOR-1 is involved in VEGF-induced endothelial cell growth

2006 ◽  
Vol 184 (2) ◽  
pp. 276-282 ◽  
Author(s):  
Jordi Rius ◽  
José Martínez-González ◽  
Javier Crespo ◽  
Lina Badimon
Keyword(s):  
Endothelial Cell ◽  
Cell Growth ◽  
Endothelial Cell Growth
Sign in / Sign up

Export Citation Format

Share Document