Vascular Endothelial Cell Growth Factor A Acts via Platelet-Derived Growth Factor Receptor α To Promote Viability of Cells Enduring Hypoxia
2016 ◽
Vol 36
(18)
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pp. 2314-2327
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Keyword(s):
Vascular endothelial cell growth factor A (VEGF) is a biologically and therapeutically important growth factor because it promotes angiogenesis in response to hypoxia, which underlies a wide variety of both physiological and pathological settings. We report here that both VEGF receptor 2 (VEGFR2)-positive and -negative cells depended on VEGF to endure hypoxia. VEGF enhanced the viability of platelet-derived growth factor receptor α (PDGFRα)-positive and VEGFR2-negative cells by enabling indirect activation of PDGFRα, thereby reducing the level of p53. We conclude that the breadth of VEGF's influence extends beyond VEGFR-positive cells and propose a plausible mechanistic explanation of this phenomenon.
2000 ◽
Vol 275
(21)
◽
pp. 15905-15911
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2000 ◽
Vol 156
(2)
◽
pp. 697-707
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2014 ◽
Vol 34
(3)
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pp. 603-615
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2001 ◽
Vol 21
(12)
◽
pp. 1934-1940
◽
1999 ◽
Vol 54
(Supplement)
◽
pp. 23-26