Combined administration of a small-molecule inhibitor of TRAF6 and Docetaxel reduces breast cancer skeletal metastasis and osteolysis

Molecule Inhibitor ◽

Combined Administration

QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

Breast Cancer Research ◽

10.1186/bcr2252 ◽

2009 ◽

Vol 11 (3) ◽

Cited By ~ 43

Author(s):

Jessica Kalra ◽

Corinna Warburton ◽

Karen Fang ◽

Lincoln Edwards ◽

Tim Daynard ◽

...

Keyword(s):

Breast Cancer ◽

Treatment Outcomes ◽

Small Molecule ◽

Cancer Model ◽

Synergistic Interactions ◽

Molecule Inhibitor ◽

Breast Cancer Model ◽

Integrin Linked Kinase

Abstract 3944: MKI-1 is a small molecule inhibitor of MASTL with antitumor and radiosensitizer activity in breast cancer cells

10.1158/1538-7445.am2019-3944 ◽

2019 ◽

Author(s):

Ah-Young Kim ◽

Jae-Sung Kim

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Small Molecule ◽

Breast Cancer Cells ◽

A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

PLoS ONE ◽

10.1371/journal.pone.0100993 ◽

2014 ◽

Vol 9 (6) ◽

pp. e100993 ◽

Cited By ~ 56

Author(s):

Fei Huang ◽

Alexander V. Mazin

Keyword(s):

Breast Cancer ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Small Molecule ◽

Therapeutic Agents ◽

Cell Killing ◽

Molecule Inhibitor ◽

Human Rad51

Faculty Opinions recommendation of MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725518097.793525480 ◽

2016 ◽

Author(s):

Scott Kaufmann ◽

Wei Meng

Keyword(s):

Breast Cancer ◽

Cell Survival ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Small Molecule ◽

Molecule Inhibitor ◽

Cancer Cell Survival

Phase 1 study of CB-839, a small molecule inhibitor of glutaminase (GLS) in combination with paclitaxel (Pac) in patients (pts) with triple negative breast cancer (TNBC).

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.15_suppl.1011 ◽

2016 ◽

Vol 34 (15_suppl) ◽

pp. 1011-1011 ◽

Cited By ~ 3

Author(s):

Angela DeMichele ◽

James J. Harding ◽

Melinda L. Telli ◽

Pamela N. Munster ◽

Rana McKay ◽

...

Keyword(s):

Breast Cancer ◽

Small Molecule ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Phase 1 ◽

Phase 1 Study ◽

Abstract 3768: Targeting of epithelial-to-mesenchyme transition by a novel small molecule inhibitor attenuates prostate and breast cancer invasiveness and bone metastases

10.1158/1538-7445.am2016-3768 ◽

2016 ◽

Author(s):

Jan Kroon ◽

Onno van Hooij ◽

Eugenio Zoni ◽

Maaike van der Mark ◽

Geertje van der Horst ◽

...

Keyword(s):

Breast Cancer ◽

Bone Metastases ◽

Small Molecule ◽

Molecule Inhibitor ◽

Cancer Invasiveness ◽

Breast Cancer Invasiveness

Abstract 3944: MKI-1 is a small molecule inhibitor of MASTL with antitumor and radiosensitizer activity in breast cancer cells

10.1158/1538-7445.sabcs18-3944 ◽

2019 ◽

Author(s):

Ah-Young Kim ◽

Jae-Sung Kim

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Small Molecule ◽

Breast Cancer Cells ◽

Abstract P2-06-02: Development of a first-in-class small molecule inhibitor (EC359) targeting oncogenic LIF/LIFR signaling for the treatment of triple negative breast cancer

10.1158/1538-7445.sabcs18-p2-06-02 ◽

2019 ◽

Author(s):

S Viswanadhapalli ◽

Y Luo ◽

GR Sareddy ◽

B Santhamma ◽

M Zhou ◽

...

Keyword(s):

Breast Cancer ◽

Small Molecule ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

A novel small molecule inhibitor of CD151 inhibits proliferation of metastatic triple negative breast cancer cell lines

Process Biochemistry ◽

10.1016/j.procbio.2017.12.004 ◽

2018 ◽

Vol 66 ◽

pp. 254-262 ◽

Cited By ~ 4

Author(s):

Murali Mohan Gavara ◽

Kunal Zaveri ◽

Anil Kumar Badana ◽

Shailender Gugalavath ◽

Krishna Chaitanya Amajala ◽

...

Keyword(s):

Breast Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Small Molecule ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Breast Cancer Cell Lines ◽

Inhibition of TACC3 by a small molecule inhibitor in breast cancer

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2018.03.125 ◽

2018 ◽

Vol 498 (4) ◽

pp. 1085-1092 ◽

Cited By ~ 7

Author(s):

Loredana Campo ◽

Eun-Kyoung Breuer

Keyword(s):

Breast Cancer ◽

Small Molecule ◽