Sulfated polysaccharide fraction from marine algae Solieria filiformis : Structural characterization, gastroprotective and antioxidant effects

2016 ◽  
Vol 152 ◽  
pp. 140-148 ◽  
Author(s):  
Willer M. Sousa ◽  
Renan O. Silva ◽  
Francisco F. Bezerra ◽  
Rudy D. Bingana ◽  
Francisco Clark N. Barros ◽  
...  
Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 918-931 ◽  
Author(s):  
Lauro M. de Souza ◽  
Guilherme L. Sassaki ◽  
Maria Teresa Villela Romanos ◽  
Eliana Barreto-Bergter

2010 ◽  
Vol 5 (8) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Ana Maria S. Assreuy ◽  
Grazielle C. Pontes ◽  
Natalia V. F. C. Rodrigues ◽  
Daniel M. Gomes ◽  
Paulo A. Xavier ◽  
...  

Anticoagulant and antithrombotic properties of sulfated-polysaccharides (SP) from marine algae are extensively exploited. However, reports on the vascular effects of SP from red algae are rare in the literature. The polysaccharide from Solieria filiformis (Sf-SP) was isolated by ion exchange chromatography, analyzed by agarose gel electrophoresis and tested in male Wistar rats. The inflammation studies were performed using the paw-edema model and the relaxant activity in isolated aorta precontracted with phenylephrine. The anticoagulant effect was evaluated by the test of partial thromboplastin activation time. The SP (1 mg/kg) was not antiinflammatory, but induced acute edema with maximal activity at 30 min (0.35 ± 0.04 mL) compared to controls (0.05 ± 0.03 mL). Cumulative addition of Sf-SP in phenylephrine-contracted tissues produced relaxation with maximal inhibition of 69% (IC50 29.3 ± 9.0 μg/mL) at 300 μg/mL in comparison to controls (0.51 ± 0.09 g). Sf-SP also extended human plasma coagulation time by 2.1 times. These substances could be used as important tools for the study of vascular alterations.


Marine Drugs ◽  
2011 ◽  
Vol 9 (11) ◽  
pp. 2188-2200 ◽  
Author(s):  
Renan Oliveira Silva ◽  
Geice Maria Pereira dos Santos ◽  
Lucas Antonio Duarte Nicolau ◽  
Larisse Tavares Lucetti ◽  
Ana Paula Macedo Santana ◽  
...  

2011 ◽  
Vol 85 (2) ◽  
pp. 394-400 ◽  
Author(s):  
Hongyan Li ◽  
Wenjun Mao ◽  
Xiuli Zhang ◽  
Xiaohui Qi ◽  
Yin Chen ◽  
...  

2013 ◽  
Vol 64 (5) ◽  
pp. 561-571 ◽  
Author(s):  
H. H. Abd El Baky ◽  
F. K. El Baz ◽  
G. S. El Baroty ◽  
O. I. Abd El-Salam ◽  
E. A. Ibrahim

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