scholarly journals Host-derived circulating cells do not significantly contribute to cardiac regeneration in heterotopic rat heart transplants

2005 ◽  
Vol 68 (3) ◽  
pp. 394-404 ◽  
Author(s):  
S AUSONI ◽  
T ZAGLIA ◽  
A DEDJA ◽  
R DILISI ◽  
M SEVESO ◽  
...  
Keyword(s):  
Rat Heart ◽  
Cardiac Regeneration ◽  
Heart Transplants ◽  
Circulating Cells

Eotaxin/CCL11 expression by infiltrating macrophages in rat heart transplants during ongoing acute rejection

2009 ◽  
Vol 87 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Martin Zweifel ◽  
Christoph Mueller ◽  
Thomas Schaffner ◽  
Clemens Dahinden ◽  
Katja Matozan ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Rat Heart ◽  
Heart Transplants

Analysis of Allogeneic and Syngeneic Rat Heart Transplants Using23Na Magnetic Resonance Spectroscopy

1996 ◽  
Vol 223 (2) ◽  
pp. 379-383 ◽  
Author(s):  
Sandra Miller Waldrop ◽  
Diane Z. Alexander ◽  
Robin Lowry ◽  
Kevin J. Winn ◽  
Thomas C. Pearson ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Rat Heart ◽  
Resonance Spectroscopy ◽  
Heart Transplants

scholarly journals Cytomegalovirus-Mediated Upregulation of Chemokine Expression Correlates with the Acceleration of Chronic Rejection in Rat Heart Transplants

2003 ◽  
Vol 77 (3) ◽  
pp. 2182-2194 ◽  
Author(s):  
Daniel N. Streblow ◽  
Craig Kreklywich ◽  
Qiang Yin ◽  
V. T. De La Melena ◽  
Christopher L. Corless ◽  
...  
Keyword(s):  
Rat Heart ◽  
Organ Transplant ◽  
Inflammatory Cells ◽  
Solid Organ ◽  
Neointimal Formation ◽  
Heart Transplants ◽  
Chemokine Expression ◽  
Vascular Infiltration ◽  
Kinetics Of ◽  
Transplant Model

ABSTRACT Cytomegalovirus (CMV) infections have been shown to dramatically affect solid organ transplant graft survival in both human and animal models. Recently, it was demonstrated that rat CMV (RCMV) infection accelerates the development of transplant vascular sclerosis (TVS) in both rat heart and small bowel graft transplants. However, the mechanisms involved in this process are still unclear. In the present study, we determined the kinetics of RCMV-accelerated TVS in a rat heart transplant model. Acute RCMV infection enhances the development of TVS in rat heart allografts, and this process is initiated between 21 and 24 days posttransplantation. The virus is consistently detected in the heart grafts from day 7 until day 35 posttransplantation but is rarely found at the time of graft rejection (day 45 posttransplantation). Grafts from RCMV-infected recipients had upregulation of chemokine expression compared to uninfected controls, and the timing of this increased expression paralleled that of RCMV-accelerated neointimal formation. In addition, graft vessels from RCMV-infected grafts demonstrate the increased infiltration of T cells and macrophages during periods of highest chemokine expression. These results suggest that CMV-induced acceleration of TVS involves the increased graft vascular infiltration of inflammatory cells through enhanced chemokine expression.

Effects of adenoviral up-regulation of bcl-2 on oxidative stress and graft coronary artery disease in rat heart transplants

2003 ◽  
Vol 76 (2) ◽  
pp. 382-386 ◽  
Author(s):  
Douglas N. Miniati ◽  
Maarten A. Lijkwan ◽  
Seiichiro Murata ◽  
Jasper Martens ◽  
Caroline T. Coleman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Rat Heart ◽  
Heart Transplants ◽  
Artery Disease
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