Stereoselective synthesis of β-arabino glycosyl sulfones as potential inhibitors of mycobacterial cell wall biosynthesis

2009 ◽  
Vol 344 (6) ◽  
pp. 739-746 ◽  
Author(s):  
Benjamin Ayers ◽  
Hilary Long ◽  
Edith Sim ◽  
Iain A. Smellie ◽  
Brendan L. Wilkinson ◽  
...  
Keyword(s):  
Cell Wall ◽  
Stereoselective Synthesis ◽  
Cell Wall Biosynthesis ◽  
Mycobacterial Cell ◽  
Mycobacterial Cell Wall ◽  
Potential Inhibitors

Synthesis of arabinose glycosyl sulfamides as potential inhibitors of mycobacterial cell wall biosynthesis

2015 ◽  
Vol 102 ◽  
pp. 153-166 ◽  
Author(s):  
Kajitha Suthagar ◽  
Andrew J.A. Watson ◽  
Brendan L. Wilkinson ◽  
Antony J. Fairbanks
Keyword(s):  
Cell Wall ◽  
Cell Wall Biosynthesis ◽  
Mycobacterial Cell ◽  
Mycobacterial Cell Wall ◽  
Potential Inhibitors

Ethambutol–sugar hybrids as potential inhibitors of mycobacterial cell-wall biosynthesis

1999 ◽  
Vol 317 (1-4) ◽  
pp. 164-179 ◽  
Author(s):  
Robert C Reynolds ◽  
Namita Bansal ◽  
Jerry Rose ◽  
Joyce Friedrich ◽  
William J Suling ◽  
...  
Keyword(s):  
Cell Wall ◽  
Cell Wall Biosynthesis ◽  
Mycobacterial Cell ◽  
Mycobacterial Cell Wall ◽  
Potential Inhibitors

Synthesis and biological evaluation of trehalose analogs as potential inhibitors of mycobacterial cell wall biosynthesis

2002 ◽  
Vol 337 (2) ◽  
pp. 105-120 ◽  
Author(s):  
Jerry D. Rose ◽  
Joseph A. Maddry ◽  
Robert N. Comber ◽  
William J. Suling ◽  
Larry N. Wilson ◽  
...  
Keyword(s):  
Cell Wall ◽  
Biological Evaluation ◽  
Cell Wall Biosynthesis ◽  
Mycobacterial Cell ◽  
Mycobacterial Cell Wall ◽  
Potential Inhibitors ◽  
Synthesis And Biological Evaluation

Hijacking of a Substrate-binding Protein Scaffold for use in Mycobacterial Cell Wall Biosynthesis

2006 ◽  
Vol 359 (4) ◽  
pp. 983-997 ◽  
Author(s):  
Zara Marland ◽  
Travis Beddoe ◽  
Leyla Zaker-Tabrizi ◽  
Isabelle S. Lucet ◽  
Rajini Brammananth ◽  
...  
Keyword(s):  
Cell Wall ◽  
Binding Protein ◽  
Substrate Binding ◽  
Cell Wall Biosynthesis ◽  
Protein Scaffold ◽  
Mycobacterial Cell ◽  
Mycobacterial Cell Wall ◽  
Substrate Binding Protein

scholarly journals Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids

Molecules ◽  
2019 ◽  
Vol 24 (19) ◽  
pp. 3596
Author(s):  
Ali ◽  
Mohammed ◽  
Dulayymi ◽  
Baird
Keyword(s):  
Cell Wall ◽  
Cell Walls ◽  
Stereoselective Synthesis ◽  
Complex Mixtures ◽  
Mycolic Acids ◽  
Mycobacterial Cell ◽  
Antigenic Properties ◽  
Mycobacterial Cell Wall ◽  
Structural Classes

Fragments of mycobacterial cell walls such as arabinoglycerol mycolate and dimycoloyl diarabinoglycerol, comprising complex mixtures of mycolic acids, have immunostimulatory and antigenic properties. A related di-mycoloyl tri-arabinofuranosyl glycerol fragment has been isolated from cell wall hydrolysates. An effective stereoselective synthesis of tri-arabinofuranosyl glycerol, followed by coupling with stereochemically defined mycolic acids of different structural classes, to provide unique di-mycoloyl tri-arabinofuranosyl glycerols is now described.

Identification of inhibitors targeting Mycobacterium tuberculosis cell wall biosynthesis via dynamic combinatorial chemistry

2017 ◽  
Vol 53 (77) ◽  
pp. 10632-10635 ◽  
Author(s):  
Jian Fu ◽  
Huixiao Fu ◽  
Marc Dieu ◽  
Iman Halloum ◽  
Laurent Kremer ◽  
...  
Keyword(s):  
Cell Wall ◽  
Mycobacterium Tuberculosis ◽  
Combinatorial Chemistry ◽  
Cell Wall Biosynthesis ◽  
Combinatorial Approach ◽  
Dynamic Combinatorial Chemistry ◽  
Mycobacterial Cell ◽  
Essential Enzyme ◽  
Mycobacterial Cell Wall

In this study, we report a dynamic combinatorial approach along with highly efficient in situ screening to identify inhibitors of UDP-galactopyranose mutase (UGM), an essential enzyme involved in mycobacterial cell wall biosynthesis.

Sign in / Sign up

Export Citation Format

Share Document