Identification of inhibitors targeting Mycobacterium tuberculosis cell wall biosynthesis via dynamic combinatorial chemistry

2017 ◽  
Vol 53 (77) ◽  
pp. 10632-10635 ◽  
Author(s):  
Jian Fu ◽  
Huixiao Fu ◽  
Marc Dieu ◽  
Iman Halloum ◽  
Laurent Kremer ◽  
...  
Keyword(s):  
Cell Wall ◽  
Mycobacterium Tuberculosis ◽  
Combinatorial Chemistry ◽  
Cell Wall Biosynthesis ◽  
Combinatorial Approach ◽  
Dynamic Combinatorial Chemistry ◽  
Mycobacterial Cell ◽  
Essential Enzyme ◽  
Mycobacterial Cell Wall

In this study, we report a dynamic combinatorial approach along with highly efficient in situ screening to identify inhibitors of UDP-galactopyranose mutase (UGM), an essential enzyme involved in mycobacterial cell wall biosynthesis.

Hijacking of a Substrate-binding Protein Scaffold for use in Mycobacterial Cell Wall Biosynthesis

2006 ◽  
Vol 359 (4) ◽  
pp. 983-997 ◽  
Author(s):  
Zara Marland ◽  
Travis Beddoe ◽  
Leyla Zaker-Tabrizi ◽  
Isabelle S. Lucet ◽  
Rajini Brammananth ◽  
...  
Keyword(s):  
Cell Wall ◽  
Binding Protein ◽  
Substrate Binding ◽  
Cell Wall Biosynthesis ◽  
Protein Scaffold ◽  
Mycobacterial Cell ◽  
Mycobacterial Cell Wall ◽  
Substrate Binding Protein

Structure of the Mycobacterium tuberculosis OmpATb protein: A model of an oligomeric channel in the mycobacterial cell wall

2010 ◽  
Vol 79 (2) ◽  
pp. 645-661 ◽  
Author(s):  
Yinshan Yang ◽  
Daniel Auguin ◽  
Stéphane Delbecq ◽  
Emilie Dumas ◽  
Gérard Molle ◽  
...  
Keyword(s):  
Cell Wall ◽  
Mycobacterium Tuberculosis ◽  
Protein A ◽  
Mycobacterial Cell ◽  
Mycobacterial Cell Wall

MYCOBACTERIAL CELL WALL EXTRACT FOR TREATMENT OF CARCINOMA IN SITU OF THE BLADDER

2001 ◽  
Vol 166 (5) ◽  
pp. 1633-1638 ◽  
Author(s):  
ALVARO MORALES ◽  
JOSEPH L. CHIN ◽  
ERNEST W. RAMSEY
Keyword(s):  
Cell Wall ◽  
Carcinoma In Situ ◽  
Mycobacterial Cell ◽  
Cell Wall Extract ◽  
Mycobacterial Cell Wall
Sign in / Sign up

Export Citation Format

Share Document