Adverse Events Associated with the Use of Guide Extension Catheters during Percutaneous Coronary Intervention: Reports from the Manufacturer and User Facility Device Experience (MAUDE) database

SummaryThe single nucleotide polymorphism (SNP) rs342293 has been shown to influence platelet number and mean platelet volume (MPV). We investigated the association between the rs342293 polymorphism and cardiovascular outcome in a prospective cohort study. The rs342293 polymorphism was analysed in 404 patients with coronary artery disease undergoing percutaneous coronary intervention. The rates of cardiac adverse events were recorded during two years of follow-up. The polymorphism was associated with MPV (median 10.1 fL, interquartile range [IQR]: 9.6 to 10.6 in patients with the CC-allele vs 10.4 fL, IQR: 9.9 to 11.1 in G>C SNP carriers; p<0.001), but not with platelet count. Survival analysis indicated that carriers of the rs342293 G variant had a substantially higher risk to develop cardiac adverse events compared with wild type carriers during two years of follow-up (33% vs 22%; adjusted hazard ratio = 1.63, 95% confidence interval = 1.06–2.52, p=0.027). The rs342293 SNP could explain 2.9% of the variability in MPV (p=0.01). In conclusion, patients undergoing coronary stenting who carry the G-variant of the rs342293 SNP which is associated with larger MPV are at higher risk for adverse cardiovascular outcome.

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1062-42 Adverse events in patients with normal renal function are increased with modest increases in creatinine clearance after percutaneous coronary intervention

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(04)90200-8 ◽

2004 ◽

Vol 43 (5) ◽

pp. A47-A48

Author(s):

Beth A Bartholomew ◽

Cindy L Grines ◽

Judith A Boura ◽

William W O'Neill

Keyword(s):

Percutaneous Coronary Intervention ◽

Renal Function ◽

Adverse Events ◽

Creatinine Clearance ◽

Normal Renal Function ◽

Coronary Intervention ◽

Percutaneous Coronary

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The ‘golden rules’ of percutaneous coronary intervention

Oxford Textbook of Interventional Cardiology ◽

10.1093/med/9780198754152.003.0006 ◽

2018 ◽

pp. 75-80

Author(s):

Rod Stables

Keyword(s):

Percutaneous Coronary Intervention ◽

Adverse Events ◽

Personal Experience ◽

Best Practice ◽

Systematic Approach ◽

Interventional Cardiology ◽

Coronary Intervention ◽

Strategic Approach ◽

Percutaneous Coronary ◽

Core Concepts

This chapter identifies general principles for the practice of interventional cardiology. The focus is on general strategic approach and the exposition of core concepts rather than details of equipment selection and manipulation. Although framed for percutaneous coronary intervention, the philosophy will translate to all forms of interventional cardiology. In contemporary activity adverse events are fortunately rare and it is very difficult for an individual operator to identify ‘best practice’ on the basis of personal experience and individual reflection. These ‘golden rules’ are based on lessons, sometimes learned at cost to patients and operators, over three decades. Knowledge of these issues and a more systematic approach may provide a framework for safe and effective practice.

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