scholarly journals Development of effective therapeutics for polysubstance use disorders

2022 ◽  
Vol 66 ◽  
pp. 102105
Author(s):  
Jinny Claire Lee ◽  
Kim D. Janda
Keyword(s):  
2021 ◽  
pp. 1-7
Author(s):  
Noa Krawczyk ◽  
Jurema C. da Mota ◽  
Carolina Coutinho ◽  
Neilane Bertoni ◽  
Mauricio T.L. de Vasconcellos ◽  
...  

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Geoff Bardwell ◽  
Tamar Austin ◽  
Lisa Maher ◽  
Jade Boyd

Abstract Background Smoking or inhaling illicit drugs can lead to a variety of negative health outcomes, including overdose. However, most overdose prevention interventions, such as supervised consumption services (SCS), prohibit inhalation. In addition, women are underrepresented at SCS and are disproportionately impacted by socio-structural violence. This study examines women’s experiences smoking illicit drugs during an overdose epidemic, including their utilization of a women-only supervised inhalation site. Methods Qualitative research methods included on-site ethnographic observation and semi-structured interviews with 32 participants purposively recruited from the women-only site. Data were coded and analyzed using NVivo 12 and thematic analysis was informed by gendered and socio-structural understandings of violence. Results Participants had preferences for smoking drugs and these were shaped by their limited income, inability to inject, and perceptions of overdose risk. Participants expressed the need for services that attend to women’s specific experiences of gendered, race-based, and structural violence faced within and outside mixed-gender social service settings. Results indicate a need for sanctioned spaces that recognize polysubstance use and drug smoking, accommodated by the women-only SCS. The smoking environment further fostered a sociability where participants could engage in perceived harm reduction through sharing drugs with other women/those in need and were able to respond in the event of an overdose. Conclusions Findings demonstrate the ways in which gendered social and structural environments shape women’s daily experiences using drugs and the need for culturally appropriate interventions that recognize diverse modes of consumption while attending to overdose and violence. Women-only smoking spaces can provide temporary reprieve from some socio-structural harms and build collective capacity to practice harm reduction strategies, including overdose prevention. Women-specific SCS with attention to polysubstance use are needed as well as continued efforts to address the socio-structural harms experienced by women who smoke illicit drugs.


2021 ◽  
Vol 56 (6) ◽  
pp. 777-781
Author(s):  
Belén del Valle Vera ◽  
José Carmona-Marquez ◽  
Claudio Vidal-Giné ◽  
Fermín Fernández-Calderón

2021 ◽  
pp. 107000
Author(s):  
Madelyn H. Labella ◽  
Rina D. Eiden ◽  
Alexandra R. Tabachnick ◽  
Tabitha Sellers ◽  
Mary Dozier

Author(s):  
Francisco Herrera-Gómez ◽  
Eduardo Gutiérrez-Abejón ◽  
Mercedes García-Mingo ◽  
F. Javier Álvarez

We are using real-life data in order to determine the prevalence of driving with the presence of cocaine and/or benzoylecgonine (BZE), their concentrations, and their use in combination with other drugs. This study assessed data on Spanish drivers with confirmed drug-positive results recorded by the Spanish National Traffic Agency from 2011–2016. Frequencies of positivity for cocaine and/or BZE and concentration of such substances were obtained. Comparisons and univariate and multivariate regression analyses were performed. Drivers who tested positive for cocaine and/or BZE accounted for 48.59% of the total positive results for drugs. In positive cases for both cocaine and BZE, other substances were detected in 81.74%: delta-9-tetrahydrocannabinol (THC) (68.19%), opioids (20.78%) and amphetamine-like substances (16.76%). In the multivariate logistic regression analysis, the frequency of cocaine and/or BZE positive cases decreased with age (OR:0.97) and were less likely among women (OR:0.63). Concentrations (ng/mL) of cocaine (249.30) and BZE (137.90) were higher when both substances were detected together than when detected alone. Positivity to cocaine represented an important proportion among Spanish drivers who tested positive for drugs, and polysubstance use was especially observed in more than 8 out of 10 positive cases for cocaine and/or BZE.


2021 ◽  
Author(s):  
Carlos D. Rivera Saldana ◽  
Daniela Abramovitz ◽  
Meredith C. Meacham ◽  
Patricia Gonzalez‐Zuniga ◽  
Claudia Rafful ◽  
...  

2021 ◽  
pp. 100197
Author(s):  
Timothy M Piatkowski ◽  
Matthew Dunn ◽  
Katherine M White ◽  
Leanne M Hides ◽  
Patricia L Obst

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