scholarly journals Matrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patients

2010 ◽  
Vol 411 (23-24) ◽  
pp. 1940-1944 ◽  
Author(s):  
Riccardo Lacchini ◽  
Anna L.B. Jacob-Ferreira ◽  
Marcelo R. Luizon ◽  
Fernanda B. Coeli ◽  
Tatiane C. Izidoro-Toledo ◽  
...  
2007 ◽  
Vol 13 (4) ◽  
pp. 287-291 ◽  
Author(s):  
N. S. Goncharova ◽  
O. M. Moiseeva ◽  
G. M. Aleshina ◽  
E. V. Shlyakhto

The study objective was to investigate serum concentrations of matrix metalloproteinase-9 (MMP-9) and it inhibitor (TIMP-1) in patients with aortic stenosis and mitral or aortic regurgitation. It was revealed that serum MMP-9 and TIMP-1 levels correlated with type of left ventricular hypertrophy. In patient with mitral or aortic regurgitation (volume load) MMP/TIMP ratio was increased due to prevalence of MMP-9. Increased serum ММР-9/TIMP-1 index was related to enlargement of left ventricular end-diastolic volume. The greatest disbalance in matrix metalloproteinase system was observed in patients with inherent connective tissue disease. In patients with pressure load hypertrophy (aortic stenosis) serum MMP blockade prevalence was observed, which promoted heart fibrosis development. Furthermore, increased serum TIMP-1 level was associated with decreased left ventricular injection fraction in patients with aortic stenosis.


Hypertension ◽  
1995 ◽  
Vol 25 (4) ◽  
pp. 651-659 ◽  
Author(s):  
Pierre Boutouyrie ◽  
Stéphane Laurent ◽  
Xavier Girerd ◽  
Athanase Benetos ◽  
Patrick Lacolley ◽  
...  

2005 ◽  
Vol 52 (4) ◽  
pp. 421-425 ◽  
Author(s):  
Ismet TAMER ◽  
Mehmet SARGIN ◽  
Haluk SARGIN ◽  
Mesut SEKER ◽  
Erhan BABALIK ◽  
...  

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