A capillary electrophoresis-based variant hotspot genotyping method for rapid and reliable analysis of the phenylalanine hydroxylase gene in the Chinese Han population

2021 ◽  
Author(s):  
Binbin Shao ◽  
An Liu ◽  
Jingjing Zhang ◽  
Yan Wang ◽  
Fengchang Qiao ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Phenylalanine Hydroxylase ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Genotyping Method ◽  
Hydroxylase Gene ◽  
Phenylalanine Hydroxylase Gene ◽  
Reliable Analysis

scholarly journals Associations between Interleukin Gene Polymorphisms and Risks of Developing Extremity Posttraumatic Osteomyelitis in Chinese Han Population

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Nan Jiang ◽  
Su-yi Li ◽  
Yun-fei Ma ◽  
Yan-jun Hu ◽  
Qing-rong Lin ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Posttraumatic Osteomyelitis ◽  
Genotyping Method ◽  
Control Study

This case-control study aimed to investigate potential associations between interleukin (IL) gene polymorphisms and the risks of developing extremity posttraumatic osteomyelitis (PTOM) in Chinese Han population. Altogether, 189 PTOM patients and 200 healthy controls were genotyped of IL-1α (rs17561, rs1800587), IL-1β (rs16944, rs1143627, rs1143634, rs2853550), IL-1RN (rs4251961, rs419598, rs315951), IL-4 (rs2243248, rs2243250), IL-6 (rs1800795, rs1800796, rs1800797), IL-8 (rs4073, rs2227306, rs2227307), IL-10 (rs3024491, rs3024496, rs1800871, rs1800872, rs1800896), IL-17A (rs2275913), and IL-17F (rs763780) using the SNaPshot genotyping method. Statistical differences were observed regarding the genotype distributions of rs16944 (P=0.049) and rs4251961 (P=0.007) between the patients and healthy controls. In addition, significant associations were found between rs16944 and the risk of PTOM development by dominant (OR=1.854, P=0.017), homozygous (OR=1.831, P=0.041), and heterozygous (OR=1.869, P=0.022) models, and of rs1143627 by dominant (OR=1.735, P=0.032) and homozygous (OR=1.839, P=0.040) models. Moreover, significant links were also identified between rs4251961 and the susceptibility to PTOM by dominant (OR=0.446, P=0.005) and heterozygous (OR=0.409, P=0.003) models, and of rs1800796 by dominant (OR=4.184, P=0.029), homozygous (OR=4.378, P=0.026), and heterozygous (OR=3.834, P=0.046) models. The present outcomes demonstrated that rs16944, rs1143627, and rs1800796 associate with increased risks, while rs4251961 links to a decreased risk of PTOM development in Chinese Han population.

Variations in genotype–phenotype correlations in phenylalanine hydroxylase deficiency in Chinese Han population

Gene ◽  
2013 ◽  
Vol 529 (1) ◽  
pp. 80-87 ◽  
Author(s):  
Tianwen Zhu ◽  
Jun Ye ◽  
Lianshu Han ◽  
Wenjuan Qiu ◽  
Huiwen Zhang ◽  
...  
Keyword(s):  
Phenylalanine Hydroxylase ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Hydroxylase Deficiency ◽  
Han Population

CYP2B6 Polymorphisms Are Associated with Ischemic Stroke Risk in a Chinese Han Population

2020 ◽  
Vol 70 (7) ◽  
pp. 1130-1139
Author(s):  
Guolong Tu ◽  
Wenliang Zhan ◽  
Yao Sun ◽  
Jiamin Wu ◽  
Zichao Xiong ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Stroke Risk ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Ischemic Stroke Risk

Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province

2014 ◽  
Vol 34 (10) ◽  
pp. 1729-1736 ◽  
Author(s):  
Xinglin Yang ◽  
Ming Li ◽  
Liya Wang ◽  
Zhongdan Hu ◽  
Yuanchao Zhang ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Genetic Polymorphisms ◽  
Shandong Province ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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