In order to test the performance of the resulting membrane oxygenator, a model was constructed to simulate the inner and extracorporeal gas exchange of the human body. The oxygenation capacity of the membrane oxygenator was studied using fresh bovine blood with added anticoagulants as the test medium. The oxygenation performance of the prepared membrane was equal to that of the commercial membrane. After six hours of operation, the oxygen saturation (SaO2) was above 95%, and the partial pressure of oxygen (PaO2) was over 13.5 kPa (100 mmHg). This model was constructed in accordance with the basic principles of extracorporeal circulation, and could be used to investigate the oxygenation performance of a membrane oxygenator, as well as to study the basic principles of extracorporeal circulation.