Three component reactions: An efficient and green synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and thiones using silica gel-supported l-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate

2013 ◽  
Vol 24 (9) ◽  
pp. 804-808 ◽  
Author(s):  
Arash Ghorbani-Choghamarani ◽  
Parisa Zamani
Keyword(s):  
Carboxylic Acid ◽  
Green Synthesis ◽  
Silica Gel ◽  
Hydrogen Sulfate

scholarly journals Green Synthesis and Antimicrobial Activity of Some Novel N-Arylimidazo[1,2-a]pyrazine-2-Carboxamide Derivatives

2019 ◽  
Vol 32 (1) ◽  
pp. 84-90 ◽  
Author(s):  
Boggavarapu Jyothi ◽  
Nannapaneni Madhavi
Keyword(s):  
Antimicrobial Activity ◽  
Carboxylic Acid ◽  
Microwave Irradiation ◽  
Green Synthesis ◽  
13C Nmr ◽  
Aromatic Amines ◽  
Condensation Reaction ◽  
Analytical Data ◽  
Ammonia Gas ◽  
1H And 13C Nmr

The article deals with the synthesis of some novel N-arylimidazo[1,2-a]pyrazine-2-carboxamides (7a-l) by condensation reaction of imidazo[1,2-a]pyrazine-2-carboxylic acid (5) with different aliphatic/aromatic amines (6a-l) by using 1-methylimidazole, Mukaiyama’s reagent and 2-chloro-1-methylpyridinium iodide under microwave irradiation conditions. A new series of compounds 7 have been prepared from 2-iodopyrazine (1). Compound 1 on purged with ammonia gas in the presence of Cu2O and K2CO3 furnishes pyrazin-2-amine (2), which is treated with ethyl 3-bromo-2-oxopropanoate (3) to produce ethyl imidazo[1,2-a]pyrazine-2-carboxylate (4), which on hydrolysis with NaOH yields imidazo[1,2-a]pyrazine-2-carboxylic acid (5). The structures of the newly synthesized compounds have been elucidated on the basis of spectral (IR, 1H and 13C NMR and MS) and analytical data. Compounds 7a-l have also been screened for their antimicrobial activity. Some of the compounds exhibit promising antimicrobial activity

Silica Gel Supported Dual Acidic Ionic Liquid as a Recyclable and Efficient Catalyst for Esterification and Acetalization Reactions

2011 ◽  
Vol 233-235 ◽  
pp. 1336-1339 ◽  
Author(s):  
Qiang Zhang ◽  
Hong Su ◽  
Jun Luo
Keyword(s):  
Ionic Liquid ◽  
Catalytic Activity ◽  
Silica Gel ◽  
Covalent Bond ◽  
High Catalytic Activity ◽  
The Novel ◽  
Hydrogen Sulfate ◽  
Efficient Catalyst ◽  
Acidic Ionic Liquid

A supported dual acidic ionic liquid was prepared via anchoring 3-sulfobutyl-1-(3-propyltriethoxysilane) imidazolium hydrogen sulfate onto common silica gel by covalent bond. The novel immobilized acidic ionic liquid illustrated high catalytic activity in esterification and acetalization reactions. The products could be separated by simple decantation and the recovered catalyst could be recycled without remarkable loss of catalytic activity even after eight runs for esterification and six runs for acetalization.

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