Design, synthesis and molecular docking of piperidin-4-amine linked pyrimidine derivatives as potent anticancer agents

2021 ◽  
pp. 100646
Author(s):  
Madhu Sudhana Reddy Gangireddy ◽  
Manohar Mantipally ◽  
Vishnu Nayak Badavath ◽  
Venkatanarayana Chowdary Maddipati ◽  
Kalyani Paidikondala ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Anticancer Agents ◽  
Pyrimidine Derivatives ◽  
Design Synthesis

Design, synthesis, and molecular docking of novel indole scaffold-based VEGFR-2 inhibitors as targeted anticancer agents

2018 ◽  
Vol 351 (2) ◽  
pp. 1700299 ◽  
Author(s):  
Hanaa M. Roaiah ◽  
Iman A. Y. Ghannam ◽  
Islam H. Ali ◽  
Ahmed M. El Kerdawy ◽  
Mamdouh M. Ali ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Anticancer Agents ◽  
Design Synthesis

DIPEAc promoted one-pot synthesis of dihydropyrido[2,3-d:6,5-d′]dipyrimidinetetraone and pyrimido[4,5-d]pyrimidine derivatives as potent tyrosinase inhibitors and anticancer agents: in vitro screening, molecular docking and ADMET predictions

2018 ◽  
Vol 42 (23) ◽  
pp. 18621-18632 ◽  
Author(s):  
Manisha R. Bhosle ◽  
Lalit D. Khillare ◽  
Jyotirling R. Mali ◽  
Aniket P. Sarkate ◽  
Deepak K. Lokwani ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Anticancer Activity ◽  
Anticancer Agents ◽  
Oral Drug ◽  
In Vitro Screening ◽  
Pyrimidine Derivatives ◽  
Rapid Synthesis ◽  
One Pot ◽  
Tyrosinase Inhibitors

Efficient and rapid synthesis of 18 tyrosinase inhibitors with good to moderate anticancer activity and good oral drug like properties.

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